SCHEMBL2436611

SCHEMBL2436611

CC(C)(Oc1cccc(C(N)CC2CCCCC2)c1)C(=O)O

nearest known ligand 0.49

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
BCL9 O00512 13/20 0.49
CTNNB1 P35222 13/20 0.49
METAP2 P50579 1/20 0.44
METAP1 P53582 1/20 0.44
PPARA Q07869 2/20 0.43
PPARG P37231 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2436610 0.74 PPARA (0.51) BCL9CTNNB1PPARAPPARG
SCHEMBL22227898 0.73 PPARA (0.51) BCL9CTNNB1PPARAPPARG
SCHEMBL5325775 0.73 PPARA (0.49) BCL9CTNNB1PPARAPPARG
SCHEMBL2436874 0.73 MEN1 (0.58) BCL9CTNNB1
SCHEMBL12927229 0.71 METAP2 (0.46) METAP2METAP1
SCHEMBL7898573 0.71 METAP2 (0.46) METAP2METAP1
SCHEMBL28660567 0.71 METAP2 (0.46) METAP2METAP1
SCHEMBL9009370 0.71 METAP2 (0.46) METAP2METAP1
SCHEMBL28672429 0.71 METAP2 (0.46) METAP2METAP1
SCHEMBL17188080 0.71 PPARA (0.52) BCL9CTNNB1PPARAPPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1433786-B1 Benzoxazole compound and pharmaceutical composition containing the compound KOWA CO (JP) 2011-09-21 EP disclosed