Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 20/20 | 0.53 |
| ▸ | LCK | P06239 | 11/20 | 0.49 |
| ▸ | MET | P08581 | 10/20 | 0.49 |
| ▸ | TEK | Q02763 | 9/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2435232 | 0.93 | KDR (0.54) | KDRLCKMETTEK | |
| SCHEMBL2435014 | 0.90 | KDR (0.52) | KDRLCKMETTEK | |
| SCHEMBL2435819 | 0.83 | KDR (0.53) | KDRLCKMETTEK | |
| SCHEMBL2709170 | 0.82 | KDR (0.57) | KDRLCKMETTEK | |
| SCHEMBL2437252 | 0.81 | RAF1 (0.53) | KDRLCKMETTEK | |
| SCHEMBL2436659 | 0.77 | CDK2 (0.72) | KDRLCKMETTEK | |
| SCHEMBL2436643 | 0.77 | CDK8 (0.61) | KDRLCKMETTEK | |
| SCHEMBL274235 | 0.76 | KDR (0.51) | KDRLCKMETTEK | |
| SCHEMBL2433982 | 0.76 | KDR (0.58) | KDRLCKMETTEK | |
| SCHEMBL2710189 | 0.74 | KDR (0.58) | KDRLCKMETTEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026247-B2 | Bicyclic amides as kinase inhibitors | NOVARTIS AG (CH) | 2011-09-27 | — | — | US | disclosed |