Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 4/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.35 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.35 |
| ▸ | CDK7 | P50613 | 1/20 | 0.35 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27451922 | 0.84 | MEN1 (0.41) | SMN1; SMN2HSD17B10KDM4EALOX15TSHR | |
| SCHEMBL27451925 | 0.84 | MEN1 (0.41) | SMN1; SMN2HSD17B10KDM4EALOX15TSHR | |
| SCHEMBL14079971 | 0.84 | MEN1 (0.41) | SMN1; SMN2HSD17B10KDM4EALOX15TSHR | |
| SCHEMBL25583715 | 0.84 | EGFR (0.33) | MEN1KMT2AEGFRERBB2BTK | |
| SCHEMBL23336391 | 0.83 | KDM4E (0.43) | SMN1; SMN2HSD17B10KDM4EALOX15TSHR | |
| SCHEMBL25583718 | 0.82 | ALDH1A1 (0.36) | SMN1; SMN2MAPK1MEN1KMT2AEGFR | |
| SCHEMBL17282927 | 0.80 | KDM4E (0.42) | SMN1; SMN2HSD17B10KDM4EALOX15TSHR | |
| SCHEMBL20927103 | 0.80 | HTT (0.49) | SMN1; SMN2HSD17B10KDM4ETSHRMAPK1 | |
| SCHEMBL19669736 | 0.80 | MEN1 (0.45) | SMN1; SMN2HSD17B10KDM4EMAPK1HIF1A | |
| SCHEMBL15600841 | 0.79 | SMN1; SMN2 (0.53) | SMN1; SMN2HSD17B10KDM4EALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3302448-B1 | SUBSTITUTED HETEROCYCLYL DERIVATIVES AS CDK INHIBITORS | AURIGENE ONCOLOGY LTD (IN) | 2023-10-25 | — | — | EP | disclosed |
| WO-2022084930-A2 | CANCER THERAPY USING A COMBINATION OF CDK7 INHIBITOR WITH AN ANTI-MICROTUBULE AGENT | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2022-04-28 | — | — | WO | disclosed |