Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | CDK7 | P50613 | 3/20 | 0.36 |
| ▸ | CDK13 | Q14004 | 3/20 | 0.36 |
| ▸ | BTK | Q06187 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 4/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15600841 | 0.88 | SMN1; SMN2 (0.53) | MEN1KMT2ASMN1; SMN2KDM4ECDK7 | |
| SCHEMBL19669735 | 0.87 | KDM4E (0.37) | MEN1KMT2ASMN1; SMN2KDM4ECDK7 | |
| SCHEMBL19669759 | 0.85 | ALDH1A1 (0.39) | MEN1KMT2ASMN1; SMN2BTKEGFR | |
| SCHEMBL19442310 | 0.83 | MEN1 (0.43) | MEN1KMT2ASMN1; SMN2KDM4ECDK7 | |
| SCHEMBL21889706 | 0.82 | MEN1 (0.42) | MEN1KMT2ASMN1; SMN2KDM4ECDK7 | |
| SCHEMBL27451925 | 0.81 | MEN1 (0.41) | MEN1KMT2ASMN1; SMN2KDM4ECDK7 | |
| SCHEMBL27451922 | 0.81 | MEN1 (0.41) | MEN1KMT2ASMN1; SMN2KDM4ECDK7 | |
| SCHEMBL14079971 | 0.81 | MEN1 (0.41) | MEN1KMT2ASMN1; SMN2KDM4ECDK7 | |
| SCHEMBL19669934 | 0.80 | SIGMAR1 (0.39) | KDM4EEGFR | |
| SCHEMBL21889962 | 0.80 | KMT2A (0.46) | MEN1KMT2ASMN1; SMN2KDM4ECDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834571-B2 | Compounds for inhibiting cell proliferation in EGFR-driven cancers | ARIAD PHARMACEUTICALS, INC. (US) | 2017-12-05 | — | — | US | disclosed |