SCHEMBL24372004

SCHEMBL24372004

COC(CO)C(O)C(C)(F)n1ccc(=O)[nH]c1=O

nearest known ligand 0.35

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
DUT P33316 11/20 0.35
PKM P14618 1/20 0.35
CRBN Q96SW2 2/20 0.33
POLB P06746 1/20 0.33
HSD17B10 Q99714 1/20 0.33
ALDH1A1 P00352 1/20 0.33
LMNA P02545 1/20 0.33
P2RY14 Q15391 2/20 0.32
P2RY2 P41231 1/20 0.32
P2RY4 P51582 1/20 0.32
P2RY6 Q15077 1/20 0.32
SLC28A1 O00337 1/20 0.32
SLC28A2 O43868 1/20 0.32
SLC29A1 Q99808 1/20 0.32
SLC28A3 Q9HAS3 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18661677 1.00 DUT (0.35) DUTPKMCRBNPOLBHSD17B10
SCHEMBL24371968 0.88 P2RY2 (0.31) P2RY2P2RY4P2RY6
SCHEMBL16566363 0.86 PKM (0.36) DUTPKMCRBNPOLBHSD17B10
SCHEMBL19881999 0.86 DUT (0.36) DUTPKMCRBNPOLBHSD17B10
SCHEMBL12031271 0.86 DUT (0.36) DUTPKMCRBNPOLBHSD17B10
SCHEMBL23790797 0.86 PKM (0.34) DUTPKMCRBN
SCHEMBL22086850 0.85 DUT (0.35) DUTPKMCRBNPOLBHSD17B10
SCHEMBL22889224 0.81 DUT (0.33) DUTLMNA
SCHEMBL22580343 0.80 P2RY2 (0.43) P2RY14P2RY2P2RY4P2RY6
SCHEMBL18636215 0.80 POLB (0.35) DUTPKMCRBNPOLBHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3043803-B1 NUCLEOTIDE AND NUCLEOSIDE COMPOSITIONS AND THEIR USES UNIV EMORY (US) 2022-04-27 EP disclosed