Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.60 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | TNKS | O95271 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7454012 | 1.00 | AKR1C3 (0.60) | AKR1C3AKR1C1CYP2C9CYP3A4TP53 | |
| SCHEMBL141612 | 1.00 | AKR1C3 (0.60) | AKR1C3AKR1C1CYP2C9CYP3A4TP53 | |
| Hydrochloric Acid SCHEMBL15862140 | 0.97 | AKR1C3 (0.58) | AKR1C3AKR1C1CYP2C9CYP3A4TP53 | |
| Hydrochloric Acid SCHEMBL15862141 | 0.97 | AKR1C3 (0.58) | AKR1C3AKR1C1CYP2C9CYP3A4TP53 | |
| Methane SCHEMBL1221501 | 0.97 | AKR1C3 (0.58) | AKR1C3AKR1C1CYP2C9CYP3A4TP53 | |
| SCHEMBL27561113 | 0.97 | AKR1C3 (0.58) | AKR1C3AKR1C1CYP2C9CYP3A4TP53 | |
| SCHEMBL28307539 | 0.97 | AKR1C3 (0.58) | AKR1C3AKR1C1CYP2C9CYP3A4TP53 | |
| Ammonia Solution, Strong SCHEMBL28233006 | 0.95 | AKR1C3 (0.56) | AKR1C3AKR1C1CYP2C9CYP3A4TP53 | |
| Sulfuric Acid SCHEMBL28985900 | 0.91 | AKR1C3 (0.52) | AKR1C3AKR1C1CYP2C9CYP3A4TP53 | |
| Phenol SCHEMBL15014256 | 0.91 | AKR1C3 (0.52) | AKR1C3AKR1C1CYP2C9CYP3A4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 381 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12076316-B2 | Levorphanol prodrugs and processes for making and using them | ZEVRA THERAPEUTICS INC. | 2024-09-03 | — | — | US | claimed |
| CN-115407010-B | Method for identifying active ingredients in edible betel nuts by using wide-range targeted metabonomics technology | 中国检验检疫科学研究院 | 2024-01-23 | — | — | CN | claimed |
| CN-115407010-A | Method for identifying active ingredients in edible areca nuts by utilizing extensive targeted metabonomics technology | 中国检验检疫科学研究院 | 2022-11-29 | — | — | CN | claimed |
| US-20220096463-A1 | LEVORPHANOL PRODRUGS AND PROCESSES FOR MAKING AND USING THEM | ALTER DOMUS (US) LLC | 2022-03-31 | — | — | US | claimed |
| US-11234975-B2 | Levorphanol prodrugs and processes for making and using them | KEMPHARM, INC. (US) | 2022-02-01 | — | — | US | claimed |
| US-20210002226-A1 | LEVORPHANOL PRODRUGS AND PROCESSES FOR MAKING AND USING THEM | ALTER DOMUS (US) LLC | 2021-01-07 | — | — | US | claimed |
| US-20200390757-A1 | LEVORPHANOL PRODRUGS AND PROCESSES FOR MAKING AND USING THEM | ALTER DOMUS (US) LLC | 2020-12-17 | — | — | US | claimed |
| WO-2018191474-A1 | LEVORPHANOL PRODRUGS AND PROCESSES FOR MAKING AND USING THEM | KEMPHARM, INC. (US) | 2018-10-18 | — | — | WO | claimed |
| WO-2018191472-A1 | LEVORPHANOL PRODRUGS AND PROCESSES FOR MAKING AND USING THEM | KEMPHARM, INC. (US) | 2018-10-18 | — | — | WO | claimed |
| US-20170312270-A1 | BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF OXYMORPHONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF | ALTER DOMUS (US) LLC | 2017-11-02 | — | — | US | claimed |
| US-20120142720-A1 | Phenylethanoic Acid, Phenylpropanoic Acid and Phenylpropenoic Acid Conjugates and Prodrugs of Hydrocodone, Methods of Making and Use Thereof | KEMPHARM, INC. (US) | 2012-06-07 | — | — | US | claimed |
| EP-2448408-A1 | PHENYLETHANOIC ACID, PHENYLPROPANOIC ACID AND PHENYLPROPENOIC ACID CONJUGATES AND PRODRUGS OF HYDROCODONE, METHODS OF MAKING AND USE THEREOF | Kempharm, Inc. (US) | 2012-05-09 | — | — | EP | claimed |
| WO-2011002995-A1 | PHENYLETHANOIC ACID, PHENYLPROPANOIC ACID AND PHENYLPROPENOIC ACID CONJUGATES AND PRODRUGS OF HYDROCODONE, METHODS OF MAKING AND USE THEREOF | KEMPHARM, INC. (US) | 2011-01-06 | — | — | WO | claimed |
| US-20110002991-A1 | PHENYLETHANOIC ACID, PHENYLPROPANOIC ACID AND PHENYLPROPENOIC ACID CONJUGATES AND PRODRUGS OF HYDROCODONE, METHOD OF MAKING AND USE THEREOF | ALTER DOMUS (US) LLC | 2011-01-06 | — | — | US | claimed |
| US-6451498-B1 | Photosensitive composition | ATOTECH DEUTSCHLAND GMBH (DE) | 2002-09-17 | — | — | US | claimed |
| EP-0864119-B1 | PHOTOSENSITIVE COMPOSITION | ATOTECH DEUTSCHLAND GMBH (DE) | 2001-02-14 | — | — | EP | claimed |
| EP-0864119-A1 | PHOTOSENSITIVE COMPOSITION | ATOTECH Deutschland GmbH (DE) | 1998-09-16 | — | — | EP | claimed |
| WO-1997020254-A1 | PHOTOSENSITIVE COMPOSITION | ATOTECH DEUTSCHLAND GMBH (DE) | 1997-06-05 | — | — | WO | claimed |
| EP-0184044-B1 | LIGHT-SENSITIVE COMPOSITION, REGISTRATION MATERIAL PREPARED THEREOF, AND PROCESS FOR OBTAINING HEAT-RESISTANT RELIEF IMAGES | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-01-15 | — | — | EP | claimed |
| EP-0184044-A2 | Light-sensitive composition, registration material prepared thereof, and process for obtaining heat-resistant relief images | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-06-11 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142720-A1 | Phenylethanoic Acid, Phenylpropanoic Acid and Phenylpropenoic Acid Conjugates and Prodrugs of Hydrocodone, Methods of Making and Use Thereof | CYP7A1, CYP2B6, CYP2D6 | AKR1C3 689/4885AKR1C1 1409/4885CYP2C9 20/4885 |
| US-20200390757-A1 | LEVORPHANOL PRODRUGS AND PROCESSES FOR MAKING AND USING THEM | OPRM1, OPRL1, OPRK1 | AKR1C3 891/4885AKR1C1 1858/4885CYP2C9 147/4885 |
| US-20170312270-A1 | BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF OXYMORPHONE, PRODRUGS, METHODS OF MAKING AND USE THEREOF | OPRM1, OPRK1, OPRD1 | AKR1C3 382/4885AKR1C1 639/4885CYP2C9 37/4885 |
| US-12076316-B2 | Levorphanol prodrugs and processes for making and using them | OPRM1, OPRL1, OPRK1 | AKR1C3 891/4885AKR1C1 1858/4885CYP2C9 147/4885 |
| US-20110002991-A1 | PHENYLETHANOIC ACID, PHENYLPROPANOIC ACID AND PHENYLPROPENOIC ACID CONJUGATES AND PRODRUGS OF HYDROCODONE, METHOD OF MAKING AND USE THEREOF | CYP7A1, CYP2B6, CYP2D6 | AKR1C3 706/4885AKR1C1 1428/4885CYP2C9 20/4885 |
| US-11234975-B2 | Levorphanol prodrugs and processes for making and using them | OPRM1, OPRL1, OPRK1 | AKR1C3 891/4885AKR1C1 1858/4885CYP2C9 147/4885 |
| US-20210002226-A1 | LEVORPHANOL PRODRUGS AND PROCESSES FOR MAKING AND USING THEM | OPRM1, OPRK1, OPRD1 | AKR1C3 542/4885AKR1C1 1337/4885CYP2C9 83/4885 |
| US-20220096463-A1 | LEVORPHANOL PRODRUGS AND PROCESSES FOR MAKING AND USING THEM | OPRM1, OPRL1, OPRK1 | AKR1C3 891/4885AKR1C1 1858/4885CYP2C9 147/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.