Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 8/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | PHGDH | O43175 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MLYCD | O95822 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.45 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19126566 | 0.81 | HPGD (0.50) | HPGDALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL10720943 | 0.76 | PHGDH (0.81) | HPGDALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL28935748 | 0.75 | MAOA (0.60) | HPGDALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL28238833 | 0.75 | HPGD (0.41) | HPGDALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL10195037 | 0.75 | MAPK10 (0.45) | HPGDALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL12871 | 0.75 | PHGDH (0.69) | HPGDALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL20657772 | 0.74 | PIK3CA (0.46) | HPGDALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL30810556 | 0.74 | PIK3CA (0.46) | HPGDALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL31227412 | 0.74 | MAOA (0.44) | ALDH1A1SMN1; SMN2KDM4EMAPTHTT | |
| SCHEMBL30402459 | 0.74 | RAB9A (0.53) | HPGDALDH1A1SMN1; SMN2MAPTPHGDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022087216-A1 | DOUBLE DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-04-28 | — | — | WO | disclosed |