Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 1/20 | 0.69 |
| ▸ | HPGD | P15428 | 5/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | HTT | P42858 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | PKM | P14618 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.62 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.58 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17194215 | 0.95 | HPGD (0.63) | PHGDHHPGDALDH1A1KDM4EMAPT | |
| SCHEMBL12947820 | 0.93 | HPGD (0.61) | PHGDHHPGDALDH1A1KDM4EMAPT | |
| SCHEMBL10720943 | 0.90 | PHGDH (0.81) | PHGDHHPGDALDH1A1KDM4EMAPT | |
| SCHEMBL25811334 | 0.89 | ALDH1A1 (0.61) | PHGDHHPGDALDH1A1KDM4EMAPT | |
| SCHEMBL17888439 | 0.87 | ALDH1A1 (0.69) | PHGDHHPGDALDH1A1KDM4EMAPT | |
| SCHEMBL10726712 | 0.86 | ALDH1A1 (0.84) | HPGDALDH1A1KDM4ELMNAPKM | |
| SCHEMBL4557193 | 0.86 | ALDH1A1 (0.84) | HPGDALDH1A1KDM4ELMNAPKM | |
| SCHEMBL12082793 | 0.85 | ALDH1A1 (0.79) | PHGDHHPGDALDH1A1KDM4EMAPT | |
| SCHEMBL1017455 | 0.85 | PHGDH (0.69) | PHGDHHPGDALDH1A1KDM4EMAPT | |
| SCHEMBL28296651 | 0.85 | HPGD (0.86) | PHGDHHPGDALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 331 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240226318-A1 | ANTIBODY DRUG CONJUGATE TARGETING NECTIN 4 AND PREPARATION METHOD THEREFOR AND USE THEREOF | Mabwell (shanghai) Bioscience Co., Ltd. (CN) | 2024-07-11 | — | — | US | disclosed |
| US-20240226318-A1 | ANTIBODY DRUG CONJUGATE TARGETING NECTIN 4 AND PREPARATION METHOD THEREFOR AND USE THEREOF | Mabwell (shanghai) Bioscience Co., Ltd. (CN) | 2024-07-11 | — | — | US | disclosed |
| CN-111574477-B | Synthesis method of amide compound | 湖南大学 | 2024-06-28 | — | — | CN | disclosed |
| WO-2024072822-A2 | DISPERSING AND WETTING AGENTS AND COMPOSITIONS AND METHODS OF USE THEREOF | MOJAVE BIO, INC. (US) | 2024-04-04 | — | — | WO | disclosed |
| WO-2024044486-A1 | JAK2 INHIBITOR COMPOUNDS | AJAX THERAPEUTICS, INC. (US) | 2024-02-29 | — | — | WO | disclosed |
| US-11912708-B2 | Macrocyclic heterocycles and uses thereof | KUMQUAT BIOSCIENCES INC. (US) | 2024-02-27 | — | — | US | disclosed |
| US-11912708-B2 | Macrocyclic heterocycles and uses thereof | KUMQUAT BIOSCIENCES INC. (US) | 2024-02-27 | — | — | US | disclosed |
| US-20230372526-A1 | PREPARATION METHOD FOR BIS-SUBSTITUTED BRIDGING ANTIBODY-DRUG CONJUGATE | Mabwell (shanghai) Bioscience Co., Ltd. (CN) | 2023-11-23 | — | — | US | disclosed |
| US-20230372526-A1 | PREPARATION METHOD FOR BIS-SUBSTITUTED BRIDGING ANTIBODY-DRUG CONJUGATE | Mabwell (shanghai) Bioscience Co., Ltd. (CN) | 2023-11-23 | — | — | US | disclosed |
| US-20230339952-A1 | MACROCYCLIC HETEROCYCLES AND USES THEREOF | KUMQUAT BIOSCIENCES INC. | 2023-10-26 | — | — | US | disclosed |
| WO-2007075468-A1 | SUBSTITUTED IMIDAZOQUINOLINES, IMIDAZONAPHTHYRIDINES, AND IMIDAZOPYRIDINES, COMPOSITIONS, AND METHODS | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2007-07-05 | — | — | WO | disclosed |
| US-20070155739-A1 | Substituted bis-amide metalloprotease inhibitors | ALANTOS PHARMACEUTICALS, INC. | 2007-07-05 | — | — | US | disclosed |
| US-20070149560-A1 | Novel fused triazolones and the uses thereof | ASTRAZENECA AB (SE) | 2007-06-28 | — | — | US | disclosed |
| US-20070149560-A1 | Novel fused triazolones and the uses thereof | ASTRAZENECA AB (SE) | 2007-06-28 | — | — | US | disclosed |
| WO-2007056341-A1 | HETEROCYCLIC MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-05-18 | — | — | WO | disclosed |
| US-20070099901-A1 | Hydroxylamine and oxime substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2007-05-03 | — | — | US | disclosed |
| US-20070099901-A1 | Hydroxylamine and oxime substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2007-05-03 | — | — | US | disclosed |
| WO-2007039544-A1 | NOVEL C18 MODIFIED RETROSTEROIDS AS PROGESTERONE RECEPTOR MODULATOR COMPOUNDS | SOLVAY PHARMACEUTICALS GMBH (DE) | 2007-04-12 | — | — | WO | disclosed |
| US-20070082876-A1 | Novel C18 modified retrosteroids as progesterone receptor modulator compounds | SOLVAY PHARMACEUTICALS GMBH (DE) | 2007-04-12 | — | — | US | disclosed |
| EP-1757582-A1 | ARYLALKYLAMINES AND PROCESS FOR PRODUCTION THEREOF | TANABE SEIYAKU CO., LTD. (JP) | 2007-02-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11912708-B2 | Macrocyclic heterocycles and uses thereof | HRAS, KRAS, TP53 | PHGDH 2010/4885HPGD 1824/4885ALDH1A1 4341/4885 |
| US-20240226318-A1 | ANTIBODY DRUG CONJUGATE TARGETING NECTIN 4 AND PREPARATION METHOD THEREFOR AND USE THEREOF | NECTIN4, HAVCR2, CD4 | PHGDH 4313/4885HPGD 4604/4885ALDH1A1 2721/4885 |
| US-20070149560-A1 | Novel fused triazolones and the uses thereof | TP53, BRCA1, KLK3 | PHGDH 3956/4885HPGD 1041/4885ALDH1A1 1270/4885 |
| US-20070099901-A1 | Hydroxylamine and oxime substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines | IFNG, IRF3, IDO1 | PHGDH 2163/4885HPGD 27/4885ALDH1A1 679/4885 |
| US-20070082876-A1 | Novel C18 modified retrosteroids as progesterone receptor modulator compounds | HSD17B11, CYP19A1, CYP17A1 | PHGDH 2357/4885HPGD 83/4885ALDH1A1 1289/4885 |
| US-20070155739-A1 | Substituted bis-amide metalloprotease inhibitors | MMP13, MMP9, ADAMTS13 | PHGDH 1275/4885HPGD 193/4885ALDH1A1 601/4885 |
| US-20230372526-A1 | PREPARATION METHOD FOR BIS-SUBSTITUTED BRIDGING ANTIBODY-DRUG CONJUGATE | FHIT, BSG, FCGRT | PHGDH 3542/4885HPGD 1746/4885ALDH1A1 465/4885 |
| US-20230339952-A1 | MACROCYCLIC HETEROCYCLES AND USES THEREOF | HRAS, KRAS, TP53 | PHGDH 2010/4885HPGD 1824/4885ALDH1A1 4341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.