Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29479125 | 1.00 | MAPT (0.34) | MAPTTRPA1HTTPTK2 | |
| SCHEMBL27096244 | 0.86 | TRPA1 (0.33) | MAPTTRPA1HTT | |
| SCHEMBL29479128 | 0.86 | TRPA1 (0.33) | MAPTTRPA1HTT | |
| SCHEMBL27096469 | 0.86 | NOS1 (0.34) | TRPA1 | |
| SCHEMBL29468945 | 0.81 | MAPT (0.49) | MAPTTRPA1HTT | |
| SCHEMBL21379213 | 0.81 | MAPT (0.49) | MAPTTRPA1HTT | |
| SCHEMBL31620771 | 0.78 | TRPA1 (0.40) | MAPTTRPA1 | |
| SCHEMBL20085466 | 0.78 | TRPA1 (0.40) | MAPTTRPA1 | |
| SCHEMBL24553739 | 0.75 | TRPA1 (0.32) | MAPTTRPA1 | |
| SCHEMBL15288252 | 0.72 | TRPA1 (0.39) | MAPTTRPA1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240059703-A1 | HETEROCYCLIC SPIRO COMPOUNDS AND METHODS OF USE | AMGEN INC. | 2024-02-22 | — | — | US | disclosed |
| WO-2022083569-A1 | HETEROCYCLIC SPIRO COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2022-04-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240059703-A1 | HETEROCYCLIC SPIRO COMPOUNDS AND METHODS OF USE | KRAS, HRAS, APC | MAPT 4629/4885TRPA1 2951/4885HTT 2143/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.