Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | OGA | O60502 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.39 |
| ▸ | OXTR | P30559 | 6/20 | 0.39 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31316711 | 0.82 | CHRNB2 (0.41) | MEN1KMT2AOGACHRNB2CHRNA4 | |
| SCHEMBL20390801 | 0.82 | CHRNB2 (0.41) | MEN1KMT2AOGACHRNB2CHRNA4 | |
| SCHEMBL26401548 | 0.80 | HTT (0.50) | HTTCHRNB2CHRNA4OPRM1MAPT | |
| SCHEMBL15925373 | 0.80 | CHRNB2 (0.40) | MEN1KMT2AOGACHRNB2CHRNA4 | |
| SCHEMBL24375517 | 0.80 | FYN (0.48) | MEN1KMT2AHTTOGACHRNB2 | |
| SCHEMBL15935407 | 0.79 | HTT (0.42) | KMT2AHTTMAPTRAB9ANPC1 | |
| SCHEMBL20594704 | 0.77 | IRAK4 (0.44) | MEN1KMT2AHTTOGACHRNB2 | |
| SCHEMBL21840502 | 0.76 | IRAK4 (0.46) | MEN1KMT2AHTTCHRNB2CHRNA4 | |
| SCHEMBL15832231 | 0.75 | RAB9A (0.41) | HTTMAPTRAB9ANPC1ATM | |
| SCHEMBL15935032 | 0.75 | ELOVL1 (0.44) | HTTOPRM1MAPTRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3642199-B1 | BENZOFURANS AS IRAK4 MODULATORS | HOFFMANN LA ROCHE (CH) | 2022-04-27 | — | — | EP | disclosed |