Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 10/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | RAD52 | P43351 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23793903 | 0.84 | MAPT (0.55) | PKMMAPTKDM4ETDP1MEN1 | |
| SCHEMBL21486288 | 0.82 | PKM (0.61) | PKMMAPTKDM4ETDP1MEN1 | |
| SCHEMBL7029404 | 0.81 | DDAH1 (0.58) | PKMMAPTKDM4ETDP1MEN1 | |
| SCHEMBL7366882 | 0.81 | PKM (0.59) | PKMTDP1RAB9AGAACYP1A2 | |
| SCHEMBL16188992 | 0.81 | PKM (0.59) | PKMMAPTTDP1MEN1KMT2A | |
| SCHEMBL8807127 | 0.79 | MAPT (0.55) | PKMMAPTKDM4ETDP1MEN1 | |
| SCHEMBL3947749 | 0.78 | RAD52 (0.53) | PKMMAPTKDM4ETDP1MEN1 | |
| SCHEMBL10289499 | 0.78 | MAPT (0.50) | PKMMAPTKDM4ETDP1MEN1 | |
| SCHEMBL6229693 | 0.77 | MAPT (0.47) | PKMMAPTKDM4ETDP1MEN1 | |
| SCHEMBL8809278 | 0.77 | MAPT (0.75) | PKMMAPTKDM4ETDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022086937-A9 | HETEROBIFUNCTIONAL COMPOUNDS AS DEGRADERS OF ENL | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2023-02-02 | — | — | WO | disclosed |
| WO-2022086937-A1 | HETEROBIFUNCTIONAL COMPOUNDS AS DEGRADERS OF ENL | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2022-04-28 | — | — | WO | disclosed |