Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 2/20 | 0.41 |
| ▸ | GLS | O94925 | 3/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22511718 | 0.79 | GRM2 (0.57) | GRM2L3MBTL1KDM4ANAMPTGLS | |
| SCHEMBL12124009 | 0.76 | CYP1A2 (0.47) | GRM2L3MBTL1PRMT5WDR77CYP1A2 | |
| SCHEMBL7447720 | 0.76 | GRM2 (0.49) | GRM2L3MBTL1CYP1A2KDM4ANAMPT | |
| SCHEMBL27757355 | 0.75 | L3MBTL1 (0.47) | GRM2L3MBTL1PRMT5WDR77CYP1A2 | |
| SCHEMBL7407052 | 0.75 | HDAC1 (0.48) | GRM2L3MBTL1KDM4ANAMPTGLS | |
| SCHEMBL16392318 | 0.74 | HDAC1 (0.47) | GRM2L3MBTL1KDM4ANAMPTGLS | |
| SCHEMBL3180689 | 0.74 | L3MBTL1 (0.61) | L3MBTL1KDM4ANAMPTMAPTTDP1 | |
| SCHEMBL16246730 | 0.74 | KLKB1 (0.52) | GRM2 | |
| SCHEMBL30386922 | 0.74 | GRM2 (0.47) | GRM2L3MBTL1CYP1A2NAMPTHDAC1 | |
| SCHEMBL25054189 | 0.74 | GRM2 (0.47) | GRM2L3MBTL1CYP1A2NAMPTHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3122344-B1 | TRKA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF | MERCK SHARP & DOHME (US) | 2022-04-27 | — | — | EP | disclosed |