Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24377814 | 0.89 | KDM4E (0.41) | KDM4EMAPTTHRBJAK1JAK2 | |
| SCHEMBL29546477 | 0.89 | KDM4E (0.41) | KDM4EMAPTTHRBJAK1JAK2 | |
| SCHEMBL16610331 | 0.88 | KDM4E (0.47) | KDM4EMAPTTHRBJAK1JAK2 | |
| SCHEMBL4775441 | 0.86 | GPR119 (0.46) | KDM4EMAPTTHRBJAK1JAK2 | |
| SCHEMBL29547014 | 0.85 | OXTR (0.42) | KDM4EJAK1JAK2TYK2JAK3 | |
| SCHEMBL24377843 | 0.85 | OXTR (0.42) | KDM4EJAK1JAK2TYK2JAK3 | |
| SCHEMBL4771971 | 0.83 | AVPR1A (0.50) | KDM4EMAPTTHRBJAK1JAK2 | |
| SCHEMBL4771288 | 0.82 | GPR119 (0.47) | KDM4EMAPTTHRBJAK1JAK2 | |
| SCHEMBL14325302 | 0.82 | KDM4E (0.51) | KDM4EMAPTTHRBCNR1MEN1 | |
| SCHEMBL22773228 | 0.81 | MAPT (0.47) | KDM4EMAPTTHRBJAK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022083560-A1 | TYK2 SELECTIVE INHIBITOR AND USE THEREOF | 南京药石科技股份有限公司 | 2022-04-28 | — | — | WO | disclosed |