Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OXTR | P30559 | 1/20 | 0.42 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.42 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 6/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 2/20 | 0.35 |
| ▸ | NAMPT | P43490 | 2/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | KRAS | P01116 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | HTR1F | P30939 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24377843 | 1.00 | OXTR (0.42) | OXTRAVPR1AEHMT2ACACBP2RX3 | |
| SCHEMBL29546477 | 0.87 | KDM4E (0.41) | EHMT2JAK1NR1H2KDM4EJAK2 | |
| SCHEMBL24377814 | 0.87 | KDM4E (0.41) | EHMT2JAK1NR1H2KDM4EJAK2 | |
| SCHEMBL24377767 | 0.85 | KDM4E (0.47) | JAK1KDM4EJAK2TYK2JAK3 | |
| SCHEMBL29138599 | 0.73 | OXTR (0.48) | OXTRAVPR1AEHMT2ACACBNR1H2 | |
| SCHEMBL16610331 | 0.73 | KDM4E (0.47) | JAK1KDM4EJAK2TYK2JAK3 | |
| SCHEMBL4775441 | 0.71 | GPR119 (0.46) | JAK1KDM4EJAK2TYK2JAK3 | |
| SCHEMBL24377909 | 0.71 | GABRP (0.56) | JAK1CYP11B2 | |
| SCHEMBL16610447 | 0.71 | JAK2 (0.48) | JAK1KDM4EJAK2TYK2JAK3 | |
| SCHEMBL30606040 | 0.70 | EHMT2 (0.41) | OXTRAVPR1AEHMT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116249526-A | TYK2 selective inhibitors and uses thereof | 南京药石科技股份有限公司 | 2023-06-09 | — | — | CN | disclosed |
| WO-2022083560-A1 | TYK2 SELECTIVE INHIBITOR AND USE THEREOF | 南京药石科技股份有限公司 | 2022-04-28 | — | — | WO | disclosed |