Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ME2 | P23368 | 1/20 | 0.33 |
| ▸ | ME1 | P48163 | 1/20 | 0.33 |
| ▸ | ME3 | Q16798 | 1/20 | 0.33 |
| ▸ | ESRRB | O95718 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ESRRA | P11474 | 1/20 | 0.33 |
| ▸ | ESRRG | P62508 | 1/20 | 0.33 |
| ▸ | HRH2 | P25021 | 5/20 | 0.33 |
| ▸ | HRH1 | P35367 | 5/20 | 0.33 |
| ▸ | CNR1 | P21554 | 2/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19635255 | 0.93 | LMNA (0.39) | MAPTGAALMNAKDM4EALDH1A1 | |
| SCHEMBL28656087 | 0.93 | LMNA (0.39) | MAPTGAALMNAKDM4EALDH1A1 | |
| SCHEMBL19635389 | 0.90 | ESRRG (0.38) | MAPTGAALMNAKDM4EALDH1A1 | |
| SCHEMBL21802201 | 0.88 | MAPT (0.37) | MAPTGAALMNAKDM4EALDH1A1 | |
| SCHEMBL21802200 | 0.88 | MAPT (0.37) | MAPTGAALMNAKDM4EALDH1A1 | |
| SCHEMBL19615217 | 0.82 | ESRRB (0.45) | MAPTLMNAALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL19635385 | 0.82 | ESRRB (0.45) | MAPTLMNAALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL19634868 | 0.75 | SMN1; SMN2 (0.47) | MAPTLMNAALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL23251241 | 0.75 | SMN1; SMN2 (0.46) | MAPTLMNAALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL19635767 | 0.73 | SMN1; SMN2 (0.45) | MAPTGAALMNAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3458459-B1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER AG (DE) | 2022-04-27 | — | — | EP | disclosed |