Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28015655 | 0.79 | MAPT (0.32) | LMNAMAPTHTTALDH1A1KDM4E | |
| SCHEMBL30425332 | 0.72 | LMNA (0.36) | LMNAKMT2AMAPTMEN1HTT | |
| SCHEMBL10582630 | 0.69 | LMNA (0.38) | LMNAKMT2AMAPTMEN1HTT | |
| SCHEMBL18052758 | 0.68 | ALDH1A1 (0.38) | KMT2AMAPTALDH1A1KDM4EGAA | |
| SCHEMBL18052759 | 0.67 | ADRB1 (0.41) | ALDH1A1KDM4EUSP2SMN1; SMN2 | |
| SCHEMBL21088278 | 0.66 | GAA (0.33) | LMNAKMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL30885476 | 0.65 | KMT2A (0.39) | LMNAKMT2AMAPTMEN1HTT | |
| SCHEMBL12662873 | 0.64 | KDM4E (0.40) | LMNAKMT2AMAPTMEN1HTT | |
| SCHEMBL18052748 | 0.64 | CHRNA7 (0.46) | LMNAKMT2AMAPTMEN1HTT | |
| SCHEMBL29868422 | 0.64 | LMNA (0.36) | LMNAKMT2AMAPTMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3458459-B1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER AG (DE) | 2022-04-27 | — | — | EP | disclosed |