Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 2/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24378656 | 0.90 | ALDH1A1 (0.42) | ALDH1A1GAAKDM4EGLAMALT1 | |
| SCHEMBL24378573 | 0.88 | ALDH1A1 (0.42) | ALDH1A1GAAKDM4EGLACFTR | |
| SCHEMBL22718383 | 0.81 | CNR2 (0.39) | ALDH1A1GAAKDM4EGLAPIK3CA | |
| SCHEMBL22718319 | 0.80 | KMO (0.44) | ALDH1A1KDM4EPIK3CA | |
| SCHEMBL27009137 | 0.78 | HPGD (0.53) | ALDH1A1KDM4E | |
| SCHEMBL22727800 | 0.78 | CNR2 (0.39) | ALDH1A1GAAKDM4EGLACFTR | |
| SCHEMBL13815641 | 0.78 | PIK3CA (0.45) | ALDH1A1KDM4EPIK3CA | |
| SCHEMBL27009144 | 0.75 | HPGD (0.49) | ALDH1A1KDM4EPIK3CACFTRMKNK1 | |
| SCHEMBL24378422 | 0.75 | KDM4E (0.42) | ALDH1A1GAAKDM4EGLAPIK3CA | |
| SCHEMBL24378634 | 0.72 | HPGD (0.43) | ALDH1A1GAAKDM4EPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022086993-A1 | NOVEL INHIBITORS OF PIKFYVE AND METHODS USING SAME | TME THERAPEUTICS LLC (US) | 2022-04-28 | — | — | WO | disclosed |