Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | CFTR | P13569 | 2/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.36 |
| ▸ | RAF1 | P04049 | 3/20 | 0.36 |
| ▸ | BRAF | P15056 | 3/20 | 0.36 |
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24378424 | 0.88 | ALDH1A1 (0.42) | ALDH1A1GAAKDM4EGLACFTR | |
| SCHEMBL24378656 | 0.87 | ALDH1A1 (0.42) | ALDH1A1GAAKDM4EGLACFTR | |
| SCHEMBL22718383 | 0.78 | CNR2 (0.39) | ALDH1A1GAAKDM4EGLACFTR | |
| SCHEMBL24378574 | 0.77 | KDM4E (0.40) | ALDH1A1GAAKDM4EGLAHPGD | |
| SCHEMBL22718319 | 0.77 | KMO (0.44) | ALDH1A1KDM4EHPGDSMN1; SMN2CYP1A2 | |
| SCHEMBL27009142 | 0.75 | HPGD (0.43) | ALDH1A1GAAKDM4EHPGDTP53 | |
| SCHEMBL27009137 | 0.74 | HPGD (0.53) | ALDH1A1KDM4EHPGDTP53SMN1; SMN2 | |
| SCHEMBL22727800 | 0.74 | CNR2 (0.39) | ALDH1A1GAAKDM4EGLACFTR | |
| SCHEMBL13815641 | 0.74 | PIK3CA (0.45) | ALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL29547619 | 0.74 | HPGD (0.48) | ALDH1A1GAAKDM4EHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022086993-A1 | NOVEL INHIBITORS OF PIKFYVE AND METHODS USING SAME | TME THERAPEUTICS LLC (US) | 2022-04-28 | — | — | WO | disclosed |