Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.49 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 8/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13776964 | 0.89 | EPHX1 (0.54) | EPHX1KDM4EMAPK1HIF1APRMT1 | |
| SCHEMBL13466509 | 0.84 | KEAP1 (0.61) | KEAP1NFE2L2EPHX1KDM4EMAPK1 | |
| SCHEMBL9547610 | 0.82 | EPHX1 (0.61) | KEAP1NFE2L2EPHX1KDM4EMAPK1 | |
| SCHEMBL19171946 | 0.82 | EPHX1 (0.61) | KEAP1NFE2L2EPHX1KDM4EMAPK1 | |
| SCHEMBL19171419 | 0.80 | EPHX1 (0.58) | KEAP1NFE2L2EPHX1KDM4EMAPK1 | |
| SCHEMBL11382117 | 0.79 | KEAP1 (0.55) | KEAP1NFE2L2EPHX1KDM4EMAPK1 | |
| SCHEMBL18902598 | 0.79 | KEAP1 (0.49) | KEAP1NFE2L2EPHX1KDM4EMAPK1 | |
| SCHEMBL10244702 | 0.79 | KEAP1 (0.49) | KEAP1NFE2L2EPHX1KDM4E | |
| SCHEMBL6285158 | 0.78 | KEAP1 (0.55) | KEAP1NFE2L2EPHX1KDM4EMAPK1 | |
| SCHEMBL10244563 | 0.77 | DNM1 (0.50) | KEAP1NFE2L2EPHX1KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3988120-A1 | NHE3-BINDING COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | Ardelyx, Inc. (US) | 2022-04-27 | — | — | EP | disclosed |