Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 18/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | IKZF2 | Q9UKS7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24379144 | 0.82 | CRBN (0.56) | CRBNDDB1 | |
| SCHEMBL24379147 | 0.82 | CRBN (0.56) | CRBNDDB1 | |
| SCHEMBL24379156 | 0.82 | CRBN (0.56) | CRBNDDB1 | |
| SCHEMBL24379153 | 0.82 | CRBN (0.56) | CRBNDDB1 | |
| SCHEMBL24379423 | 0.79 | ABCC9 (0.40) | CRBNDDB1 | |
| SCHEMBL24379148 | 0.78 | CRBN (0.31) | CRBN | |
| SCHEMBL24379143 | 0.76 | ADAM17 (0.41) | CRBNDDB1IKZF2 | |
| SCHEMBL24379145 | 0.76 | CRBN (0.31) | CRBNDDB1 | |
| SCHEMBL21025830 | 0.75 | CRBN (0.68) | CRBNDDB1IKZF2 | |
| SCHEMBL20128660 | 0.74 | CRBN (0.37) | CRBNPDE3BPDE3AIKZF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022087125-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR PROTEIN | ARVINAS OPERATIONS, INC. (US) | 2022-04-28 | — | — | WO | disclosed |