Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.40 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24384545 | 0.78 | MAPT (0.40) | MAPTSMN1; SMN2GAALMNATSHR | |
| SCHEMBL28494938 | 0.74 | LRRK2 (0.40) | MAPTSMN1; SMN2GAALMNATSHR | |
| SCHEMBL24384656 | 0.69 | PRKDC (0.48) | MAPTSMN1; SMN2NPC1RAB9AALOX15 | |
| SCHEMBL24384551 | 0.68 | GAA (0.45) | MAPTSMN1; SMN2GAATSHRALDH3A1 | |
| SCHEMBL28496580 | 0.67 | PIK3CD (0.54) | MAPK14 | |
| SCHEMBL24195955 | 0.66 | PIK3CA (0.47) | MAPTSMN1; SMN2GAALMNATSHR | |
| SCHEMBL23595648 | 0.65 | DRD2 (0.37) | MAPTKDM4EALDH1A1 | |
| SCHEMBL29173402 | 0.63 | MAPT (0.50) | MAPTSMN1; SMN2GAALMNATSHR | |
| SCHEMBL518971 | 0.63 | LGMN (0.54) | MAPTSMN1; SMN2GAALMNATSHR | |
| SCHEMBL29173627 | 0.63 | MAPT (0.47) | MAPTSMN1; SMN2GAALMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3992189-A1 | QUINAZOLINE AND CINNOLINE DERIVATIVES AS DNA-PK INHIBITOR | Medshine Discovery Inc. (CN) | 2022-05-04 | — | — | EP | disclosed |