Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | STAT3 | P40763 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL912707 | 0.61 | POLB (0.35) | KMT2AMEN1ALOX15HTTNPSR1 | |
| SCHEMBL28091427 | 0.59 | KMT2A (0.36) | KMT2AMEN1ALOX15HTTNPSR1 | |
| SCHEMBL16117369 | 0.57 | SMN1; SMN2 (0.48) | KMT2AMEN1NPSR1MAPTSMN1; SMN2 | |
| SCHEMBL19027031 | 0.56 | MAPT (0.35) | KMT2AMEN1ALOX15HTTNPSR1 | |
| SCHEMBL3996473 | 0.54 | MAPT (0.56) | KMT2AMEN1ALOX15HTTMAPT | |
| SCHEMBL17204101 | 0.54 | MAPT (0.61) | KMT2AMEN1HTTNPSR1MAPT | |
| SCHEMBL17673774 | 0.54 | MAPT (0.56) | KMT2AMEN1HTTNPSR1MAPT | |
| SCHEMBL1735480 | 0.54 | CNR2 (0.55) | KMT2AMEN1ALOX15HTTMAPT | |
| SCHEMBL29465738 | 0.54 | MAPT (0.43) | KMT2AMEN1ALOX15HTTNPSR1 | |
| SCHEMBL856718 | 0.54 | MAPT (0.61) | KMT2AMEN1HTTNPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3239135-B1 | PYRIMIDONE COMPOUNDS USED AS LP-PLA2 INHIBITORS AND PHARMACEUTICAL COMPOSITIONS THEREOF | SHANGHAI INST MATERIA MEDICA CAS (CN) | 2022-05-04 | — | — | EP | disclosed |