Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5170761 | 0.63 | MAPT (0.37) | MAPTCYP1A2CYP2D6HTTSMN1; SMN2 | |
| SCHEMBL1735480 | 0.62 | CNR2 (0.55) | MAPTCYP1A2ALOX15HTTSMN1; SMN2 | |
| SCHEMBL856718 | 0.62 | MAPT (0.61) | MAPTCYP1A2CYP2D6HTTNPSR1 | |
| SCHEMBL17204101 | 0.62 | MAPT (0.61) | MAPTCYP1A2CYP2D6HTTNPSR1 | |
| SCHEMBL17673774 | 0.62 | MAPT (0.56) | MAPTCYP1A2CYP2D6HTTNPSR1 | |
| SCHEMBL23467846 | 0.62 | POLB (0.58) | CYP1A2HTTNPSR1POLBKMT2A | |
| SCHEMBL3996473 | 0.62 | MAPT (0.56) | MAPTCYP1A2CYP2D6ALOX15HTT | |
| SCHEMBL1617856 | 0.62 | MAPT (0.56) | MAPTCYP1A2CYP2D6HTTNPSR1 | |
| SCHEMBL21690 | 0.62 | MAPT (0.66) | MAPTCYP1A2ALOX15HTTSMN1; SMN2 | |
| SCHEMBL9508287 | 0.62 | MAPT (0.66) | MAPTCYP1A2HTTSMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3983413-A1 | SUBSTITUTED PYRAZOLO-PYRAZINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | Janssen Pharmaceutica NV (BE) | 2022-04-20 | — | — | EP | disclosed |