Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 19/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2436690 | 0.78 | PTGS1 (0.54) | APPKDM4ENPC1ALDH1A1 | |
| SCHEMBL4246721 | 0.72 | RAB9A (0.53) | APPNPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL2086625 | 0.72 | KDM4E (0.63) | APPKDM4ENPC1ALDH1A1MAPT | |
| SCHEMBL1733303 | 0.72 | ALDH1A1 (0.38) | KDM4ENPC1ALDH1A1MAPTPKM | |
| SCHEMBL9760182 | 0.72 | PTGS1 (0.58) | KDM4ENPC1ALDH1A1MAPTPKM | |
| Bromide SCHEMBL3774680 | 0.71 | KDM4E (0.61) | APPKDM4ENPC1ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL9120456 | 0.71 | PTGS1 (0.57) | KDM4ENPC1ALDH1A1MAPTPKM | |
| SCHEMBL8863213 | 0.70 | ALDH1A1 (0.40) | APPKDM4ENPC1ALDH1A1MAPT | |
| SCHEMBL1733339 | 0.70 | ALDH1A3 (0.38) | ALDH1A1 | |
| SCHEMBL1733882 | 0.70 | LRRK2 (0.40) | KDM4ENPC1ALDH1A1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2225241-B1 | Derivatives of N-phenyl-imidazo-(1,2-A)-pyridine-2-carboxamides, preparation thereof and therapeutic application thereof | SANOFI SA (FR) | 2011-09-14 | — | — | EP | claimed |