Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL538163 | 0.84 | LMNA (0.44) | ESR1LMNAKDM4EGAAALDH1A1 | |
| SCHEMBL21768434 | 0.84 | LMNA (0.35) | ESR1LMNAKDM4EGAAALDH1A1 | |
| SCHEMBL27507519 | 0.81 | LMNA (0.43) | ESR1LMNAKDM4ETP53L3MBTL1 | |
| SCHEMBL12181175 | 0.80 | LMNA (0.51) | LMNAKDM4EGAAALDH1A1HPGD | |
| SCHEMBL938534 | 0.79 | LMNA (0.43) | LMNAKDM4EGAAALDH1A1HPGD | |
| SCHEMBL19105615 | 0.76 | CNR1 (0.38) | ESR1LMNAKDM4EGAATP53 | |
| SCHEMBL13169975 | 0.74 | LMNA (0.46) | LMNAKDM4EGAAALDH1A1HPGD | |
| SCHEMBL15148105 | 0.73 | GRN (0.48) | ESR1LMNAKDM4EGAAALDH1A1 | |
| SCHEMBL14671569 | 0.73 | GAA (0.34) | LMNAKDM4EGAATP53L3MBTL1 | |
| SCHEMBL537472 | 0.72 | HDAC3 (0.41) | LMNAKDM4EALDH1A1POLBHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4238974-A1 | HIGH-ACTIVITY WNT PATHWAY INHIBITOR COMPOUND | Adlai Nortye Biopharma Co., Ltd. (CN) | 2023-09-06 | — | — | EP | disclosed |
| WO-2022089454-A1 | HIGH-ACTIVITY WNT PATHWAY INHIBITOR COMPOUND | 杭州阿诺生物医药科技有限公司 | 2022-05-05 | — | — | WO | disclosed |