Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.38 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MPO | P05164 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL538163 | 0.85 | LMNA (0.44) | LMNAKDM4ETP53L3MBTL1POLB | |
| SCHEMBL23402761 | 0.82 | GRN (0.44) | KDM4EGAAALDH1A1 | |
| SCHEMBL1591305 | 0.79 | MPO (0.44) | LMNASTIM1ORAI1KDM4ETP53 | |
| SCHEMBL24401110 | 0.79 | ESR1 (0.37) | LMNAKDM4ETP53L3MBTL1POLB | |
| SCHEMBL13169975 | 0.79 | LMNA (0.46) | LMNAKDM4ETP53L3MBTL1POLB | |
| SCHEMBL8322070 | 0.78 | LMNA (0.55) | LMNAKDM4ETP53L3MBTL1POLB | |
| SCHEMBL769183 | 0.78 | LMNA (0.41) | LMNASTIM1ORAI1KDM4ETP53 | |
| SCHEMBL13184397 | 0.78 | MPO (0.43) | LMNASTIM1ORAI1KDM4ETP53 | |
| SCHEMBL15148105 | 0.78 | GRN (0.48) | LMNAKDM4EPOLBTSHRHDAC3 | |
| SCHEMBL16564299 | 0.77 | MPO (0.42) | LMNASTIM1ORAI1KDM4ETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4653423-A1 | PYRAZOL-5-ETHER COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | CAC Nantong Chemical Co., Ltd. (CN) | 2025-11-26 | — | — | EP | disclosed |
| WO-2024199260-A1 | PYRAZOL-5-ETHER COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 南通泰禾化工股份有限公司 | 2024-10-03 | — | — | WO | disclosed |
| CN-118702628-A | Pyrazole-5-ether compound as well as preparation method and application thereof | 南通泰禾化工股份有限公司 | 2024-09-27 | — | — | CN | disclosed |
| US-20160151337-A1 | ANNELATED PYRROLES AND THEIR USE AS CRAC INHIBITORS | GRUENENTHAL GMBH (DE) | 2016-06-02 | — | — | US | disclosed |
| WO-2015022073-A1 | ANNELATED PYRROLES AND THEIR USE AS CRAC INHIBITORS | Grünenthal GmbH (DE) | 2015-02-19 | — | — | WO | disclosed |
| WO-2013092463-A1 | 4-AZAINDOLE INHIBITORS OF CRAC | F. HOFFMANN-LA ROCHE AG (CH) | 2013-06-27 | — | — | WO | disclosed |
| WO-2013092467-A1 | 7-AZAINDOLE INHIBITORS OF CRAC | F. HOFFMANN-LA ROCHE AG (CH) | 2013-06-27 | — | — | WO | disclosed |
| WO-2013092444-A1 | DIAZAINDOLE INHIBITORS OF CRAC | F. HOFFMANN-LA ROCHE AG (CH) | 2013-06-27 | — | — | WO | disclosed |
| WO-2013092463-A1 | 4-AZAINDOLE INHIBITORS OF CRAC | F. HOFFMANN-LA ROCHE AG (CH) | 2013-06-27 | — | — | WO | disclosed |
| WO-2013092444-A1 | DIAZAINDOLE INHIBITORS OF CRAC | F. HOFFMANN-LA ROCHE AG (CH) | 2013-06-27 | — | — | WO | disclosed |
| US-20110071150-A1 | INDOLE DERIVATIVES AS CRAC MODULATORS | ALAM MUZAFFAR | 2011-03-24 | — | — | US | disclosed |
| US-7875606-B2 | Herbicides; selectivity between crops and weeds | IHARA CHEMICAL INDUSTRY CO., LTD. (JP) | 2011-01-25 | — | — | US | disclosed |
| EP-1405853-B1 | ISOXAZOLINE DERIVATIVES AND HERBICIDES | KUMIAI CHEMICAL INDUSTRY CO (JP) | 2010-11-03 | — | — | EP | disclosed |
| US-7435830-B2 | Bicyclic and bridged nitrogen heterocycles | CHEMOCENTRYX, INC. (US) | 2008-10-14 | — | — | US | disclosed |
| US-20040259734-A1 | Izoxazoline derivative and herbicide | IHARA CHEMICAL INDUSTRY CO., LTD. (JP) | 2004-12-23 | — | — | US | disclosed |
| EP-1405853-A1 | ISOXAZOLINE DERIVATIVES AND HERBICIDES | KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) | 2004-04-07 | — | — | EP | disclosed |
| EP-0789698-B1 | N-(1-ETHYL-4-PYRAZOLYL)TRIAZOLOAZINESULFONAMIDE HERBICIDES | DOW AGROSCIENCES LLC (US) | 1999-07-07 | — | — | EP | disclosed |
| US-5763359-A | N-(1-ethyl-4-pyrazolyl)triazoloazinesulfonamide herbicides | DOW AGROSCIENCES LLC (US) | 1998-06-09 | — | — | US | disclosed |
| EP-0789698-A1 | N-(1-ETHYL-4-PYRAZOLYL)TRIAZOLOAZINESULFONAMIDE HERBICIDES | DOWELANCO (US) | 1997-08-20 | — | — | EP | disclosed |
| WO-1997008172-A1 | N-(1-ETHYL-4-PYRAZOLYL)TRIAZOLOAZINESULFONAMIDE HERBICIDES | DOWELANCO (US) | 1997-03-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110071150-A1 | INDOLE DERIVATIVES AS CRAC MODULATORS | ORAI1, RYR2, CACNA1E | LMNA 2616/4885STIM1 61/4885ORAI1 1/4885 |
| US-20040259734-A1 | Izoxazoline derivative and herbicide | HCN4, HDHD5, KCNJ1 | LMNA 4793/4885STIM1 2873/4885ORAI1 4095/4885 |
| US-20160151337-A1 | ANNELATED PYRROLES AND THEIR USE AS CRAC INHIBITORS | AADAC, PRRC2C, PRRC2A | LMNA 2660/4885STIM1 316/4885ORAI1 87/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.