Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 7/20 | 0.49 |
| ▸ | RAB9A | P51151 | 7/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.48 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.48 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24405601 | 0.82 | LMNA (0.56) | LMNANPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL24405365 | 0.82 | LMNA (0.56) | LMNANPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL24405968 | 0.80 | LMNA (0.50) | LMNANPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL24405622 | 0.80 | ALDH1A1 (0.53) | LMNANPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL24405466 | 0.80 | ALDH1A1 (0.53) | LMNANPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL24405728 | 0.80 | ALDH1A1 (0.50) | LMNANPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL24405683 | 0.79 | LMNA (0.49) | LMNANPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL24405500 | 0.79 | ALDH1A1 (0.49) | LMNANPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL24405673 | 0.78 | LMNA (0.48) | LMNANPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL12121057 | 0.71 | NPC1 (0.70) | LMNANPC1RAB9ASMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3774739-B1 | FUSED CYCLIC UREA DERIVATIVES AS CRHR2 ANTAGONIST | RAQUALIA PHARMA INC (JP) | 2022-05-11 | — | — | EP | disclosed |