Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.54 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.54 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24405601 | 1.00 | LMNA (0.56) | LMNANPC1RAB9ATAS1R3TAS1R1 | |
| SCHEMBL24406137 | 0.88 | TAS1R3 (0.52) | LMNANPC1RAB9ATAS1R3TAS1R1 | |
| SCHEMBL24405594 | 0.87 | TAS1R3 (0.57) | NPC1RAB9ATAS1R3TAS1R1TAS1R2 | |
| SCHEMBL24405480 | 0.87 | TAS1R3 (0.57) | NPC1RAB9ATAS1R3TAS1R1TAS1R2 | |
| SCHEMBL21474035 | 0.86 | CRHR1 (0.61) | NPC1RAB9A | |
| SCHEMBL24405803 | 0.86 | NPC1 (0.54) | LMNANPC1RAB9ACYP1A2CYP2C19 | |
| SCHEMBL30419484 | 0.85 | SSTR4 (0.51) | HPGDALDH1A1KDM4ECNR2 | |
| SCHEMBL24405518 | 0.83 | LMNA (0.51) | LMNANPC1RAB9ATAS1R3TAS1R1 | |
| SCHEMBL24405702 | 0.82 | LMNA (0.50) | LMNANPC1RAB9ATAS1R3TAS1R1 | |
| SCHEMBL24405968 | 0.82 | LMNA (0.50) | LMNANPC1RAB9ATAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3774739-B1 | FUSED CYCLIC UREA DERIVATIVES AS CRHR2 ANTAGONIST | RAQUALIA PHARMA INC (JP) | 2022-05-11 | — | — | EP | disclosed |