Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.42 |
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SCD | O00767 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24408853 | 0.88 | KMT2A (0.36) | KMT2AHTR2B | |
| SCHEMBL4343729 | 0.83 | SIGMAR1 (0.42) | HTR2ADRD2SIGMAR1SCD | |
| SCHEMBL23508661 | 0.78 | KMT2A (0.36) | KMT2AHTR2B | |
| SCHEMBL24408813 | 0.78 | CHRNB2 (0.41) | HTR2ASIGMAR1HTR2CHTR2B | |
| SCHEMBL5317315 | 0.77 | HTR2A (0.64) | HTR2ADRD2SIGMAR1HTR2CADRA1D | |
| SCHEMBL22520498 | 0.74 | IRAK4 (0.37) | KMT2AHTR2B | |
| SCHEMBL24408928 | 0.74 | — | — | |
| SCHEMBL24408842 | 0.74 | CCNC (0.42) | HTR2ADRD2SIGMAR1ADRA1DADRA1A | |
| SCHEMBL19852145 | 0.73 | SIGMAR1 (0.46) | HTR2ADRD2SIGMAR1HTR2CADRA1D | |
| SCHEMBL13005014 | 0.72 | DRD2 (0.46) | HTR2ADRD2SIGMAR1HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022095971-A1 | SPIRO HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海医药集团股份有限公司 | 2022-05-12 | — | — | WO | disclosed |