Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 6/20 | 0.44 |
| ▸ | GSK3B | P49841 | 5/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 2/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.43 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | WNT1 | P04628 | 2/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24424559 | 0.81 | KDM4E (0.52) | ROCK2HPGDKDM4ELTA4HMAPT | |
| SCHEMBL25090710 | 0.80 | ROCK2 (0.44) | DYRK1AGSK3BROCK2HPGDKDM4E | |
| SCHEMBL25090827 | 0.79 | KLKB1 (0.47) | ROCK2F2ABL1HPGDKDM4E | |
| SCHEMBL27731712 | 0.75 | WDR5 (0.47) | GSK3BROCK2ABL1MAPTLMNA | |
| SCHEMBL27711111 | 0.74 | ABL1 (0.45) | DYRK1AGSK3BROCK2ABL1KDM4E | |
| SCHEMBL10285108 | 0.74 | KDM4E (0.51) | DYRK1AGSK3BKDM4EMAPTLMNA | |
| SCHEMBL22606683 | 0.74 | CHRM4 (0.56) | DYRK1AGSK3BKDM4EWNT1MAPT | |
| SCHEMBL29584860 | 0.73 | SMO (0.37) | MAPT | |
| SCHEMBL13621106 | 0.72 | GAA (0.67) | KDM4EHSD17B10MAPTLMNA | |
| SCHEMBL4764375 | 0.70 | ROCK2 (0.52) | DYRK1AGSK3BROCK2ABL1WNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022099144-A1 | ΡΡΑRγ MODULATORS AND METHODS OF USE | Eisai R&D Mangement Co., Ltd. (JP) | 2022-05-12 | — | — | WO | disclosed |