Sugi Predict

Sugi Predict / Compounds / SCHEMBL24425259

SCHEMBL24425259

SCHEMBL24425259

CCC(C(N)C(=O)O)C(F)(F)F

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ SLC7A5 Q01650 2/20 0.41
▸ SLC1A3 P43003 3/20 0.38
▸ SLC1A2 P43004 3/20 0.38
▸ SLC1A1 P43005 3/20 0.38
▸ PTGS1 P23219 2/20 0.34
▸ SLC7A11 Q9UPY5 1/20 0.34
▸ USP2 O75604 1/20 0.33
▸ SLCO1B1 Q9Y6L6 1/20 0.33
▸ ALDH1A1 P00352 1/20 0.32
▸ MAPT P10636 1/20 0.32
▸ DPP8 Q6V1X1 3/20 0.32
▸ DPP7 Q9UHL4 2/20 0.32
▸ DPP4 P27487 1/20 0.32
▸ NOS3 P29474 1/20 0.32
▸ NOS1 P29475 1/20 0.32
▸ NOS2 P35228 1/20 0.32
▸ GLO1 Q04760 1/20 0.32
▸ GRIK1 P39086 1/20 0.31
▸ GRIK2 Q13002 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3696339 0.76 TDP1 (0.36) SLC1A3SLC1A2SLC1A1
Hydrochloric Acid SCHEMBL6874562 0.72 NOS2 (0.35) SLC7A5SLC1A3SLC1A2SLC1A1NOS3
SCHEMBL25722618 0.72 CETP (0.36) —
Isoleucine SCHEMBL5575078 0.71 DPP8 (0.52) SLC7A5DPP8DPP7DPP4
Isoleucine SCHEMBL5575081 0.71 DPP8 (0.52) SLC7A5DPP8DPP7DPP4
Isoleucine SCHEMBL7440879 0.71 DPP8 (0.52) SLC7A5DPP8DPP7DPP4
SCHEMBL4419903 0.70 SLC7A5 (0.52) SLC7A5SLC1A3SLC1A2SLC1A1PTGS1
SCHEMBL4426649 0.70 SLC7A5 (0.52) SLC7A5SLC1A3SLC1A2SLC1A1PTGS1
SCHEMBL189157 0.70 SLC7A5 (0.52) SLC7A5SLC1A3SLC1A2SLC1A1PTGS1
SCHEMBL189158 0.70 SLC7A5 (0.52) SLC7A5SLC1A3SLC1A2SLC1A1PTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250099424-A1 Nitrile-Containing Antiviral Compounds PFIZER INC. (US) 2025-03-27 — — US disclosed
EP-4516301-A2 NITRILE-CONTAINING COMPOUNDS FOR USE AS MEDICAMENTS Pfizer Inc. (US) 2025-03-05 — — EP disclosed
EP-4166539-B1 NITRILE-CONTAINING COMPOUNDS FOR USE AS MEDICAMENTS PFIZER (US) 2024-10-09 — — EP disclosed
CN-114681443-B Nitrile-containing antiviral compounds 辉瑞大药厂 2024-05-10 — — CN disclosed
CN-116789648-A Nitrile-containing antiviral compounds 辉瑞大药厂 2023-09-22 — — CN disclosed
CN-114466838-B Nitrile-containing antiviral compounds 辉瑞大药厂 2023-05-02 — — CN disclosed
US-20230120254-A1 Nitrile-Containing Antiviral Compounds PFIZER INC. (US) 2023-04-20 — — US disclosed
EP-4166539-A1 NITRILE-CONTAINING COMPOUNDS FOR USE AS MEDICAMENTS Pfizer Inc. (US) 2023-04-19 — — EP disclosed
US-11541034-B2 Nitrile-containing antiviral compounds PFIZER INC. (US) 2023-01-03 — — US disclosed
US-11541034-B2 Nitrile-containing antiviral compounds PFIZER INC. (US) 2023-01-03 — — US disclosed
US-11452711-B2 Nitrile-containing antiviral compounds PFIZER INC. (US) 2022-09-27 — — US disclosed
US-20220257563-A1 Nitrile-Containing Antiviral Compounds PFIZER INC. (US) 2022-08-18 — — US disclosed
CN-114681443-A Nitrile-containing antiviral compounds 辉瑞大药厂 2022-07-01 — — CN disclosed
US-11351149-B2 Nitrile-containing antiviral compounds PFIZER INC. (US) 2022-06-07 — — US disclosed
US-11351149-B2 Nitrile-containing antiviral compounds PFIZER INC. (US) 2022-06-07 — — US disclosed
US-20220142976-A1 Nitrile-Containing Antiviral Compounds PFIZER INC. (US) 2022-05-12 — — US disclosed
US-20220142976-A1 Nitrile-Containing Antiviral Compounds PFIZER INC. (US) 2022-05-12 — — US disclosed
CN-114466838-A Nitrile-containing antiviral compounds 辉瑞大药厂 2022-05-10 — — CN disclosed
EP-3953330-A1 NITRILE-CONTAINING ANTIVIRAL COMPOUNDS Pfizer Inc. (US) 2022-02-16 — — EP disclosed
WO-2021250648-A1 NITRILE-CONTAINING ANTIVIRAL COMPOUNDS PFIZER INC. (US) 2021-12-16 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220257563-A1 Nitrile-Containing Antiviral Compounds ACE2, NOS2, EIF2AK2 SLC7A5 3787/4885SLC1A3 4168/4885SLC1A2 3950/4885
US-11452711-B2 Nitrile-containing antiviral compounds ACE2, NOS2, EIF2AK2 SLC7A5 3787/4885SLC1A3 4168/4885SLC1A2 3950/4885
US-20230120254-A1 Nitrile-Containing Antiviral Compounds ACE2, NOS2, EIF2AK2 SLC7A5 3787/4885SLC1A3 4168/4885SLC1A2 3950/4885
US-20250099424-A1 Nitrile-Containing Antiviral Compounds ACE2, NOS2, EIF2AK2 SLC7A5 3787/4885SLC1A3 4168/4885SLC1A2 3950/4885
US-20220142976-A1 Nitrile-Containing Antiviral Compounds ACE2, NOS2, EIF2AK2 SLC7A5 3787/4885SLC1A3 4168/4885SLC1A2 3950/4885
US-11541034-B2 Nitrile-containing antiviral compounds ACE2, NOS2, EIF2AK2 SLC7A5 3787/4885SLC1A3 4168/4885SLC1A2 3950/4885
US-11351149-B2 Nitrile-containing antiviral compounds ACE2, NOS2, EIF2AK2 SLC7A5 3787/4885SLC1A3 4168/4885SLC1A2 3950/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.