Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 4/20 | 0.62 |
| ▸ | JAK2 | O60674 | 2/20 | 0.59 |
| ▸ | FLT3 | P36888 | 4/20 | 0.56 |
| ▸ | STAT6 | P42226 | 2/20 | 0.56 |
| ▸ | AXL | P30530 | 1/20 | 0.54 |
| ▸ | KIT | P10721 | 2/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.53 |
| ▸ | SYK | P43405 | 4/20 | 0.53 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.53 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.52 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28442012 | 0.86 | JAK2 (0.57) | JAK2FLT3STAT6SYK | |
| SCHEMBL30135476 | 0.86 | JAK3 (0.65) | JAK3JAK2FLT3STAT6AXL | |
| SCHEMBL28441100 | 0.85 | JAK2 (0.61) | JAK3JAK2FLT3STAT6SYK | |
| SCHEMBL30135524 | 0.85 | JAK3 (0.66) | JAK3JAK2FLT3STAT6AXL | |
| SCHEMBL28897517 | 0.84 | LRRK2 (0.53) | JAK3JAK2FLT3STAT6KIT | |
| SCHEMBL24426180 | 0.84 | JAK2 (0.77) | JAK3JAK2FLT3AXLFGFR1 | |
| SCHEMBL28897516 | 0.80 | PTK2 (0.60) | JAK3PTK2 | |
| SCHEMBL29669890 | 0.78 | JAK2 (0.75) | JAK3JAK2FLT3SYK | |
| SCHEMBL28437339 | 0.78 | JAK2 (0.75) | JAK3JAK2FLT3SYK | |
| SCHEMBL1020619 | 0.77 | SYK (0.64) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111423384-B | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2021-10-15 | — | — | CN | claimed |
| CN-111423384-A | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2020-07-17 | — | — | CN | claimed |
| CN-111423384-B | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2021-10-15 | — | — | CN | disclosed |
| CN-111423384-A | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2020-07-17 | — | — | CN | disclosed |