Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 8/20 | 0.63 |
| ▸ | FLT3 | P36888 | 5/20 | 0.63 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.44 |
| ▸ | JAK3 | P52333 | 2/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28437348 | 0.92 | JAK2 (0.64) | JAK2FLT3FGFR4POLBALDH1A1 | |
| SCHEMBL28441098 | 0.89 | JAK2 (0.61) | JAK2FLT3FGFR4POLBALDH1A1 | |
| SCHEMBL28443652 | 0.87 | JAK2 (0.64) | JAK2FLT3FGFR4POLBALDH1A1 | |
| SCHEMBL22860801 | 0.86 | JAK2 (0.82) | JAK2FLT3POLBALDH1A1MAPT | |
| SCHEMBL28447917 | 0.84 | MAPK9 (0.44) | JAK2FLT3FGFR4POLBJAK3 | |
| SCHEMBL24426201 | 0.84 | JAK2 (0.64) | JAK2FLT3POLBALDH1A1PIK3R1 | |
| SCHEMBL28437346 | 0.81 | JAK2 (0.64) | JAK2FLT3FGFR4POLBALDH1A1 | |
| SCHEMBL29236036 | 0.79 | JAK2 (0.70) | JAK2FLT3POLBALDH1A1MAPT | |
| SCHEMBL28435361 | 0.79 | JAK2 (0.63) | JAK2FLT3FGFR4POLBALDH1A1 | |
| SCHEMBL24426203 | 0.79 | JAK2 (0.63) | JAK2FLT3FGFR4JAK3MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111423384-B | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2021-10-15 | — | — | CN | disclosed |
| CN-111423384-A | 2-aminopyrimidine compounds and application thereof | 沈阳药科大学 | 2020-07-17 | — | — | CN | disclosed |