Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.38 |
| ▸ | MTOR | P42345 | 2/20 | 0.38 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2520544 | 0.77 | PIK3CB (0.39) | PIK3CBPIK3CAPIK3CDPIK3R1PIK3CG | |
| SCHEMBL12802461 | 0.77 | CTSL (0.42) | PIK3CBPIK3CAPIK3CDPIK3CGALDH1A1 | |
| SCHEMBL4786599 | 0.68 | CETP (0.58) | L3MBTL1MAPTPIK3CBPIK3CAPIK3CD | |
| SCHEMBL8801187 | 0.67 | PIK3CA (0.47) | L3MBTL1MAPTPIK3CAMTORPTGS2 | |
| SCHEMBL1308905 | 0.65 | MAPT (0.61) | L3MBTL1MAPTPIK3CAPIK3R1MTOR | |
| SCHEMBL38827 | 0.65 | MAPT (0.57) | L3MBTL1MAPTPIK3CAPIK3R1MTOR | |
| SCHEMBL14161647 | 0.64 | MAPT (0.43) | L3MBTL1MAPTPIK3CBPIK3CAPIK3CD | |
| SCHEMBL14161664 | 0.64 | MAPT (0.43) | L3MBTL1MAPTPIK3CBPIK3CAPIK3CD | |
| SCHEMBL29434918 | 0.63 | PIK3CB (0.88) | PIK3CBPIK3CAPIK3CDPIK3R1PIK3CG | |
| SCHEMBL477634 | 0.63 | PIK3CB (0.88) | PIK3CBPIK3CAPIK3CDPIK3R1PIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2547684-A1 | SPIROCYCLIC COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS AND DIAGNOSTIC PROBES | University of Basel (CH) | 2013-01-23 | — | — | EP | disclosed |
| WO-2011114275-A1 | SPIROCYCLIC COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS AND DIAGNOSTIC PROBES | UNIVERSITY OF BASEL (CH) | 2011-09-22 | — | — | WO | disclosed |