Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 18/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 17/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 13/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 10/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2442701 | 0.77 | L3MBTL1 (0.38) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL2442130 | 0.74 | PIK3CD (0.69) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL30819019 | 0.72 | JAK3 (0.44) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL2442888 | 0.69 | PIK3CA (0.62) | PIK3CAPIK3R1 | |
| SCHEMBL30818736 | 0.68 | JAK3 (0.49) | — | |
| SCHEMBL12802461 | 0.67 | CTSL (0.42) | PIK3CBPIK3CDPIK3CAPIK3CGHTT | |
| SCHEMBL30818936 | 0.67 | JAK3 (0.46) | PIK3CDPIK3CA | |
| SCHEMBL2593015 | 0.64 | PIK3CD (0.80) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL30818687 | 0.62 | JAK3 (0.43) | — | |
| SCHEMBL30818954 | 0.62 | KMO (0.50) | PIK3CAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2547684-A1 | SPIROCYCLIC COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS AND DIAGNOSTIC PROBES | University of Basel (CH) | 2013-01-23 | — | — | EP | disclosed |
| WO-2011114275-A1 | SPIROCYCLIC COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS AND DIAGNOSTIC PROBES | UNIVERSITY OF BASEL (CH) | 2011-09-22 | — | — | WO | disclosed |