Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 10/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.44 |
| ▸ | SCN1A | P35498 | 2/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.44 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.44 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24427241 | 0.80 | CYP2A6 (0.43) | SCN10AKCNH2SCN1ASCN5ASCN9A | |
| SCHEMBL6927527 | 0.75 | ALDH1A1 (0.54) | SCN5ASCN9AALDH1A1HSD17B10KDM4E | |
| SCHEMBL24428023 | 0.75 | CREBBP (0.37) | ALDH1A1HSD17B10KDM4EMEN1POLB | |
| SCHEMBL10273623 | 0.70 | ABL1 (0.48) | ALDH1A1HSD17B10CYP3A4TSHRTDP1 | |
| SCHEMBL7789671 | 0.70 | TDP1 (0.47) | SCN5AALDH1A1HSD17B10KDM4EMEN1 | |
| SCHEMBL24427383 | 0.69 | CYP2A6 (0.41) | CYP2A6MAPTL3MBTL1 | |
| SCHEMBL24427567 | 0.69 | CYP2A6 (0.53) | SCN10ASCN2ACYP2A6NPY5RALDH1A1 | |
| SCHEMBL3673207 | 0.69 | CYP3A4 (0.46) | ALDH1A1HSD17B10MAPTMAPK1KMT2A | |
| SCHEMBL4439767 | 0.69 | AAK1 (0.49) | ALDH1A1HSD17B10KDM4EMEN1POLB | |
| SCHEMBL15507790 | 0.69 | PDE3B (0.48) | KCNH2CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11518766-B2 | Tricyclic compound, preparation method therefor and use thereof | SHANGHAI JEMINCARE PHARMACEUTICALS CO., LTD. (CN) | 2022-12-06 | — | — | US | disclosed |
| EP-3998263-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | Shanghai Jemincare Pharmaceuticals Co., Ltd. (CN) | 2022-05-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11518766-B2 | Tricyclic compound, preparation method therefor and use thereof | TFPI, TFPI2, F11 | SCN10A 1157/4885KCNH2 2686/4885SCN1A 881/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.