SCHEMBL7789671

SCHEMBL7789671

Nc1ccc(-c2ccc(N)c(OC(F)(F)F)c2)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 5/20 0.47
CYP3A4 P08684 5/20 0.47
ALDH1A1 P00352 4/20 0.47
HSD17B10 Q99714 4/20 0.47
TSHR P16473 2/20 0.47
KIF11 P52732 2/20 0.44
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
KDM4E B2RXH2 1/20 0.43
POLB P06746 1/20 0.43
MAPT P10636 1/20 0.43
HPGD P15428 1/20 0.43
MAPK1 P28482 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
TP53 P04637 1/20 0.41
TAAR1 Q96RJ0 2/20 0.40
CREBBP Q92793 1/20 0.39
PDK2 Q15119 1/20 0.36
DHFR P00374 1/20 0.35
SYK P43405 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6927527 0.92 ALDH1A1 (0.54) TDP1CYP3A4ALDH1A1HSD17B10TSHR
SCHEMBL28929835 0.87 HSD17B10 (0.46) TDP1CYP3A4ALDH1A1HSD17B10TSHR
SCHEMBL4439767 0.84 AAK1 (0.49) TDP1CYP3A4ALDH1A1HSD17B10TSHR
SCHEMBL31533760 0.84 GAA (0.39) TDP1CYP3A4ALDH1A1HSD17B10TSHR
SCHEMBL6310104 0.84 GAA (0.39) TDP1CYP3A4ALDH1A1HSD17B10TSHR
SCHEMBL31533686 0.83 PDE3B (0.43) TDP1CYP3A4ALDH1A1HSD17B10TSHR
SCHEMBL31533743 0.82 ALDH1A1 (0.41) TDP1CYP3A4ALDH1A1HSD17B10TSHR
SCHEMBL4911777 0.82 KIF11 (0.46) TDP1CYP3A4ALDH1A1HSD17B10TSHR
SCHEMBL31533756 0.79 ALDH1A1 (0.40) TDP1CYP3A4ALDH1A1HSD17B10TSHR
SCHEMBL22815715 0.79 KMO (0.47) TDP1CYP3A4ALDH1A1TSHRKIF11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0758000-B1 Polyimide films from pyromellitic dianhydride and 2,2'-bis(perfluoroalkoxy)benzidines as alignment layers for liquid crystal displays DU PONT (US) 2001-12-19 EP claimed
WO-2025074873-A1 POLYAMIDIMIDE, RESIN COMPOSITION, MOLDED ARTICLE, AND FILM 株式会社カネカ 2025-04-10 WO disclosed
WO-2025063230-A1 POLYIMIDE, RESIN COMPOSITION, MOLDED OBJECT, AND FILM 株式会社カネカ 2025-03-27 WO disclosed
EP-0615527-A1 ARAMID BLOCK COPOLYMERS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1994-09-21 EP disclosed
EP-0601063-A1 FLUORINE-CONTAINING DIAMINES, POLYAMIDES, AND POLYIMIDES. DU PONT (US) 1994-06-15 EP disclosed
WO-1993011180-A1 ARAMID BLOCK COPOLYMERS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1993-06-10 WO disclosed
WO-1993004033-A1 FLUORINE-CONTAINING DIAMINES, POLYAMIDES, AND POLYIMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1993-03-04 WO disclosed