Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDLR | P01130 | 1/20 | 0.53 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.52 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.52 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.49 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | MLYCD | O95822 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | ESRRG | P62508 | 1/20 | 0.48 |
| ▸ | TNF | P01375 | 1/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.48 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.48 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24429262 | 0.91 | CHRM4 (0.60) | CHRM4NPC1RAB9AMLYCDACHE | |
| SCHEMBL22919723 | 0.88 | CXCR4 (0.61) | LDLRCXCR4ADAMTS4ADAMTS5HDAC6 | |
| SCHEMBL10724023 | 0.88 | LDLR (0.62) | LDLRCXCR4HDAC6NPC1RAB9A | |
| SCHEMBL10720889 | 0.85 | CXCR4 (0.65) | LDLRCXCR4ADAMTS4ADAMTS5HDAC6 | |
| SCHEMBL17483890 | 0.82 | HDAC6 (0.58) | LDLRCXCR4HDAC6NPC1RAB9A | |
| SCHEMBL5242088 | 0.82 | CXCR4 (0.51) | LDLRCXCR4ADAMTS4ADAMTS5HDAC6 | |
| SCHEMBL8396478 | 0.81 | SMN1; SMN2 (0.68) | LDLRNPC1RAB9AL3MBTL1ACHE | |
| SCHEMBL8395193 | 0.81 | SMN1; SMN2 (0.68) | LDLRNPC1RAB9AL3MBTL1ACHE | |
| SCHEMBL16182351 | 0.80 | HSD17B10 (0.53) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8393679 | 0.79 | ACHE (0.66) | LDLRNPC1RAB9AL3MBTL1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220153722-A1 | CDK2/5 DEGRADERS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220153722-A1 | CDK2/5 DEGRADERS AND USES THEREOF | CDK2, CDK5, CDK5R1 | LDLR 2604/4885CXCR4 2268/4885CHRM4 4632/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.