Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | RAB9A | P51151 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | ACHE | P22303 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | LDLR | P01130 | 1/20 | 0.55 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.54 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8396478 | 1.00 | SMN1; SMN2 (0.68) | SMN1; SMN2RAB9AALDH1A1GAAACHE | |
| SCHEMBL8393679 | 0.98 | ACHE (0.66) | SMN1; SMN2RAB9AALDH1A1GAAACHE | |
| SCHEMBL8391438 | 0.95 | ACHE (0.66) | SMN1; SMN2RAB9AALDH1A1GAAACHE | |
| SCHEMBL8393574 | 0.92 | ACHE (0.69) | SMN1; SMN2RAB9AALDH1A1GAAACHE | |
| SCHEMBL10724023 | 0.92 | LDLR (0.62) | SMN1; SMN2RAB9AALDH1A1GAAACHE | |
| SCHEMBL8391413 | 0.91 | SMN1; SMN2 (0.64) | SMN1; SMN2RAB9AALDH1A1GAAACHE | |
| SCHEMBL8393231 | 0.91 | SMN1; SMN2 (0.64) | SMN1; SMN2RAB9AALDH1A1GAAACHE | |
| SCHEMBL10720512 | 0.89 | ITGB3 (0.64) | SMN1; SMN2RAB9AALDH1A1GAAACHE | |
| SCHEMBL8391362 | 0.89 | SMN1; SMN2 (0.62) | SMN1; SMN2RAB9AALDH1A1GAAACHE | |
| SCHEMBL24429262 | 0.86 | CHRM4 (0.60) | SMN1; SMN2RAB9AACHENPC1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5864043-A | CARDIOVASCULAR DISORDERS AND ANGIOTENSIN ANTAGONIST | KARL THOMAE GMBH (DE) | 1999-01-26 | — | — | US | disclosed |
| US-5541229-A | ANGIOITENSIN II ANTAGONIST AS HYPOTENSIVE AGENTS, ANTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |