Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.43 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | GSTO1 | P78417 | 2/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24429353 | 0.85 | KDM4E (0.37) | LMNASLC12A2SLC12A5GLAALDH1A1 | |
| SCHEMBL22648438 | 0.80 | MCL1 (0.59) | ALDH1A1POLBMEN1KMT2AMAPT | |
| SCHEMBL19590542 | 0.79 | MEN1 (0.42) | LMNAALDH1A1POLBKDM4EMEN1 | |
| SCHEMBL24429433 | 0.78 | ALDH1A1 (0.46) | LMNAGLAALDH1A1POLBKDM4E | |
| SCHEMBL29651879 | 0.78 | GSTO1 (0.45) | LMNAALDH1A1POLBKMT2ASMN1; SMN2 | |
| SCHEMBL299708 | 0.78 | GSTO1 (0.45) | LMNAALDH1A1POLBKMT2ASMN1; SMN2 | |
| SCHEMBL12932911 | 0.77 | ALDH1A1 (0.47) | LMNASLC12A2SLC12A5GLAALDH1A1 | |
| SCHEMBL21028383 | 0.77 | ALDH1A1 (0.44) | LMNAALDH1A1POLBKDM4EMEN1 | |
| SCHEMBL17507368 | 0.77 | MEN1 (0.54) | LMNAALDH1A1POLBKDM4EMEN1 | |
| SCHEMBL289875 | 0.76 | CA2 (0.50) | GSTO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220153734-A1 | Pyrazolopyridine Compounds For IRE1 Inhibition | Optikira, LLC | 2022-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220153734-A1 | Pyrazolopyridine Compounds For IRE1 Inhibition | XBP1, ERN1, ERN2 | LMNA 1449/4885SLC12A2 4449/4885SLC12A5 4252/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.