Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Morphine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 8/20 | 0.89 |
| ▸ | OPRD1 | P41143 | 9/20 | 0.89 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.89 |
| ▸ | MRGPRX2 | Q96LB1 | 2/20 | 0.89 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.89 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.89 |
| ▸ | ARRB1 | P49407 | 1/20 | 0.89 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Morphine SCHEMBL8374708 | 0.99 | OPRD1 (0.90) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL149700 | 0.99 | OPRD1 (0.90) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL15055206 | 0.99 | OPRD1 (0.90) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL27790641 | 0.95 | OPRD1 (0.90) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL29245643 | 0.95 | OPRD1 (0.98) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL31298106 | 0.95 | OPRD1 (0.98) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL1314201 | 0.95 | OPRD1 (0.98) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL3369901 | 0.95 | OPRD1 (0.98) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL6238952 | 0.95 | OPRD1 (0.98) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 | |
| Morphine SCHEMBL7532547 | 0.95 | OPRD1 (0.98) | OPRD1OPRM1OPRK1MRGPRX2SLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0767663-B1 | COMPOSITION COMPRISING MORPHINE, POLYPYRROLIDONE AND A POLYALKYLENEOXIDE | ALZA CORP (US) | 2002-04-03 | — | — | EP | claimed |
| EP-0767663-A1 | COMPOSITION COMPRISING MORPHINE, POLYPYRROLIDONE AND A POLYALKYLENEOXIDE | ALZA CORPORATION (US) | 1997-04-16 | — | — | EP | claimed |
| US-5593695-A | Morphine therapy | ALZA CORPORATION (US) | 1997-01-14 | — | — | US | claimed |
| WO-1996000066-A1 | COMPOSITION COMPRISING MORPHINE, POLYPYRROLIDONE AND A POLYALKYLENEOXIDE | ALZA CORPORATION (US) | 1996-01-04 | — | — | WO | claimed |
| US-8524277-B2 | Extended release dosage form | ALZA CORPORATION (US) | 2013-09-03 | — | — | US | disclosed |
| US-20110229533-A1 | EXTENDED RELEASE DOSAGE FORM | ALZA CORPORATION (US) | 2011-09-22 | — | — | US | disclosed |
| EP-1600154-B1 | Osmotic extended-release dosage form | ALZA CORP (US) | 2010-11-03 | — | — | EP | disclosed |
| US-20070128279-A1 | Extended Release Dosage Form | ALZA CORPORATION (US) | 2007-06-07 | — | — | US | disclosed |
| EP-1600154-A1 | Osmotic extended-release dosage form | Alza Corporation (US) | 2005-11-30 | — | — | EP | disclosed |
| EP-1059916-B1 | EXTENDED RELEASE DOSAGE FORM | ALZA CORP (US) | 2005-11-02 | — | — | EP | disclosed |
| EP-1384471-A1 | Osmotic extented-release dosage form | ALZA CORPORATION (US) | 2004-01-28 | — | — | EP | disclosed |
| EP-0767663-B1 | COMPOSITION COMPRISING MORPHINE, POLYPYRROLIDONE AND A POLYALKYLENEOXIDE | ALZA CORP (US) | 2002-04-03 | — | — | EP | disclosed |
| US-6245357-B1 | CONTAINING HYDROMORPHONE, ACETAMINOPHEN AND CARRIER | ALZA CORPORATION | 2001-06-12 | — | — | US | disclosed |
| EP-1059916-A1 | EXTENDED RELEASE DOSAGE FORM | ALZA CORPORATION (US) | 2000-12-20 | — | — | EP | disclosed |
| WO-1999044591-A1 | EXTENDED RELEASE DOSAGE FORM | ALZA CORPORATION (US) | 1999-09-10 | — | — | WO | disclosed |
| US-5667805-A | Morphine therapy | ALZA CORPORATION (US) | 1997-09-16 | — | — | US | disclosed |
| EP-0767663-A1 | COMPOSITION COMPRISING MORPHINE, POLYPYRROLIDONE AND A POLYALKYLENEOXIDE | ALZA CORPORATION (US) | 1997-04-16 | — | — | EP | disclosed |
| US-5593695-A | Morphine therapy | ALZA CORPORATION (US) | 1997-01-14 | — | — | US | disclosed |
| WO-1996000066-A1 | COMPOSITION COMPRISING MORPHINE, POLYPYRROLIDONE AND A POLYALKYLENEOXIDE | ALZA CORPORATION (US) | 1996-01-04 | — | — | WO | disclosed |
| US-5460826-A | Morphine therapy | ALZA CORPORATION (US) | 1995-10-24 | — | — | US | disclosed |