SCHEMBL24433403

SCHEMBL24433403

O=C(Nc1cccnn1)C1CC12CCNCC2

nearest known ligand 0.41

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MAP4K1 Q92918 8/20 0.41
FFAR2 O15552 1/20 0.38
PDF Q9HBH1 1/20 0.38
ALDH1A1 P00352 1/20 0.36
PTGER4 P35408 1/20 0.36
FPR2 P25090 1/20 0.35
FAAH O00519 1/20 0.35
HPGD P15428 2/20 0.34
LMNA P02545 1/20 0.34
HCRTR1 O43613 1/20 0.34
HCRTR2 O43614 1/20 0.34
JAK2 O60674 1/20 0.34
GOT1 P17174 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31195181 0.81 FAAH (0.39) MAP4K1FFAR2PDFALDH1A1PTGER4
SCHEMBL26619952 0.81 FAAH (0.39) MAP4K1FFAR2PDFALDH1A1PTGER4
SCHEMBL24433424 0.77 DYRK1A (0.41) MAP4K1FFAR2PDFALDH1A1HPGD
SCHEMBL30522718 0.77 JAK2 (0.51) JAK2
SCHEMBL24433402 0.77 JAK2 (0.51) JAK2
SCHEMBL24433497 0.77 CYP1A2 (0.48) ALDH1A1HPGDLMNAHCRTR1HCRTR2
SCHEMBL24433518 0.76 NTRK3 (0.51) MAP4K1ALDH1A1LMNA
SCHEMBL24433504 0.74 MGLL (0.44)
SCHEMBL24433420 0.74 MGLL (0.44)
SCHEMBL24433506 0.74 MGLL (0.44)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4574150-A2 A MAGL INHIBITOR H. Lundbeck A/S (DK) 2025-06-25 EP disclosed
EP-4244208-B1 A MAGL INHIBITOR H LUNDBECK AS (DK) 2025-04-02 EP disclosed
US-20240018120-A1 MAGL INHIBITORS H. LUNDBECK A/S (DK) 2024-01-18 US disclosed
US-20240018120-A1 MAGL INHIBITORS H. LUNDBECK A/S (DK) 2024-01-18 US disclosed
US-20240018120-A1 MAGL INHIBITORS H. LUNDBECK A/S (DK) 2024-01-18 US disclosed
CN-116547274-A MAGL inhibitors H.隆德贝克有限公司 2023-08-04 CN disclosed
US-11434222-B2 MAGL inhibitors H. LUNDBECK A/S (DK) 2022-09-06 US disclosed
US-20220153721-A1 MAGL INHIBITORS H. LUNDBECK A/S (DK) 2022-05-19 US disclosed
WO-2022101412-A1 A MAGL INHIBITOR H. LUNDBECK A/S (DK) 2022-05-19 WO disclosed
US-20220153721-A1 MAGL INHIBITORS H. LUNDBECK A/S (DK) 2022-05-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11434222-B2 MAGL inhibitors MAG, MAGI3, MAGT1 MAP4K1 510/4885FFAR2 2027/4885PDF 3493/4885
US-20240018120-A1 MAGL INHIBITORS MAG, MAGI3, MAGT1 MAP4K1 510/4885FFAR2 2027/4885PDF 3493/4885
US-20220153721-A1 MAGL INHIBITORS MAG, MAGI3, MAGT1 MAP4K1 510/4885FFAR2 2027/4885PDF 3493/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.