Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 7/20 | 0.39 |
| ▸ | Q9HBH1 | 1/20 | 0.38 | |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31195181 | 1.00 | FAAH (0.39) | FAAHPDFJAK2JAK1NAMPT | |
| SCHEMBL24433402 | 0.85 | JAK2 (0.51) | JAK2JAK1NAMPT | |
| SCHEMBL30522718 | 0.85 | JAK2 (0.51) | JAK2JAK1NAMPT | |
| SCHEMBL27008613 | 0.84 | HCRTR2 (0.50) | HCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL27008487 | 0.84 | HCRTR2 (0.50) | HCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL24433506 | 0.82 | MGLL (0.44) | — | |
| SCHEMBL29657032 | 0.82 | MGLL (0.44) | — | |
| SCHEMBL24433420 | 0.82 | MGLL (0.44) | — | |
| SCHEMBL24433504 | 0.82 | MGLL (0.44) | — | |
| SCHEMBL24433403 | 0.81 | MAP4K1 (0.41) | FAAHPDFJAK2FFAR2MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119137114-A | Crystalline forms of (S) -1- (pyridazin-3-ylcarbamoyl) -6-azaspiro [2.5] octane-6-carboxylic acid 1, 3-hexafluoropropan-2-ester as monoacylglycerol lipase inhibitors | H.隆德贝克有限公司 | 2024-12-13 | — | — | CN | claimed |
| WO-2023213854-A1 | CRYSTALLINE FORM OF 1,1,1,3,3,3-HEXAFLUOROPROPAN-2-YL (S)-1-(PYRIDAZIN-3-YLCARBAMOYL)-6 AZASPIRO[2.5]OCTANE-6-CARBOXYLATE AS MONOACYLGLYCEROL LIPASE INHIBITOR. | H. LUNDBECK A/S (DK) | 2023-11-09 | — | — | WO | claimed |
| CN-119137114-A | Crystalline forms of (S) -1- (pyridazin-3-ylcarbamoyl) -6-azaspiro [2.5] octane-6-carboxylic acid 1, 3-hexafluoropropan-2-ester as monoacylglycerol lipase inhibitors | H.隆德贝克有限公司 | 2024-12-13 | — | — | CN | disclosed |
| CN-119137114-A | Crystalline forms of (S) -1- (pyridazin-3-ylcarbamoyl) -6-azaspiro [2.5] octane-6-carboxylic acid 1, 3-hexafluoropropan-2-ester as monoacylglycerol lipase inhibitors | H.隆德贝克有限公司 | 2024-12-13 | — | — | CN | disclosed |
| CN-119137114-A | Crystalline forms of (S) -1- (pyridazin-3-ylcarbamoyl) -6-azaspiro [2.5] octane-6-carboxylic acid 1, 3-hexafluoropropan-2-ester as monoacylglycerol lipase inhibitors | H.隆德贝克有限公司 | 2024-12-13 | — | — | CN | disclosed |
| WO-2023213854-A1 | CRYSTALLINE FORM OF 1,1,1,3,3,3-HEXAFLUOROPROPAN-2-YL (S)-1-(PYRIDAZIN-3-YLCARBAMOYL)-6 AZASPIRO[2.5]OCTANE-6-CARBOXYLATE AS MONOACYLGLYCEROL LIPASE INHIBITOR. | H. LUNDBECK A/S (DK) | 2023-11-09 | — | — | WO | disclosed |