Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.49 |
| ▸ | MMP9 | P14780 | 2/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.48 |
| ▸ | TACR1 | P25103 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ACP3 | P15309 | 1/20 | 0.43 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.43 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.43 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.43 |
| ▸ | MME | P08473 | 1/20 | 0.43 |
| ▸ | ACE | P12821 | 1/20 | 0.43 |
| ▸ | CPA1 | P15085 | 1/20 | 0.43 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22445561 | 1.00 | MTNR1A (0.49) | MTNR1AMMP9MMP2MMP8CTNNB1 | |
| SCHEMBL24704675 | 0.83 | L3MBTL1 (0.50) | MTNR1AMMP9CTNNB1TACR1ATM | |
| SCHEMBL22255848 | 0.83 | L3MBTL1 (0.50) | MTNR1AMMP9CTNNB1TACR1ATM | |
| SCHEMBL29478371 | 0.82 | TDP1 (0.57) | MTNR1AMMP9CTNNB1TACR1TDP1 | |
| SCHEMBL1927058 | 0.82 | TDP1 (0.57) | MTNR1AMMP9CTNNB1TACR1TDP1 | |
| SCHEMBL29478364 | 0.82 | TDP1 (0.57) | MTNR1AMMP9CTNNB1TACR1TDP1 | |
| SCHEMBL29568355 | 0.82 | TDP1 (0.57) | MTNR1AMMP9CTNNB1TACR1TDP1 | |
| SCHEMBL289220 | 0.82 | TDP1 (0.57) | MTNR1AMMP9CTNNB1TACR1TDP1 | |
| SCHEMBL2027675 | 0.82 | TDP1 (0.57) | MTNR1AMMP9CTNNB1TACR1TDP1 | |
| Hydrochloric Acid SCHEMBL1926014 | 0.81 | TDP1 (0.56) | MTNR1ACTNNB1TACR1TDP1ACP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3941452-A1 | SMALL MOLECULES TARGETING THE INTRINSICALLY DISORDERED STRUCTURAL ENSEMBLE OF ALPHA-SYNUCLEIN PROTECT AGAINST DIVERSE ALPHA-SYNUCLEIN MEDIATED DYSFUNCTIONS | The Regents of the University of California (US) | 2022-01-26 | — | — | EP | claimed |
| US-12553889-B2 | Small molecules targeting the intrinsically disordered structural ensemble of α-synuclein protect against diverse α-synuclein mediated dysfunctions | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2026-02-17 | — | — | US | disclosed |
| US-20220155287-A1 | SMALL MOLECULES TARGETING THE INTRINSICALLY DISORDERED STRUCTURAL ENSEMBLE OF ALPHA-SYNUCLEIN PROTECT AGAINST DIVERSE ALPHA-SYNUCLEIN MEDIATED DYSFUNCTIONS | UNIV CALIFORNIA (US) | 2022-05-19 | — | — | US | disclosed |
| US-20220155287-A1 | SMALL MOLECULES TARGETING THE INTRINSICALLY DISORDERED STRUCTURAL ENSEMBLE OF ALPHA-SYNUCLEIN PROTECT AGAINST DIVERSE ALPHA-SYNUCLEIN MEDIATED DYSFUNCTIONS | UNIV CALIFORNIA (US) | 2022-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220155287-A1 | SMALL MOLECULES TARGETING THE INTRINSICALLY DISORDERED STRUCTURAL ENSEMBLE OF ALPHA-SYNUCLEIN PROTECT AGAINST DIVERSE ALPHA-SYNUCLEIN MEDIATED DYSFUNCTIONS | SNCA, PARK7, SYNCRIP | MTNR1A 2215/4885MMP9 4241/4885MMP2 4033/4885 |
| US-12553889-B2 | Small molecules targeting the intrinsically disordered structural ensemble of α-synuclein protect against diverse α-synuclein mediated dysfunctions | SNCA, PARK7, HTT | MTNR1A 2339/4885MMP9 4310/4885MMP2 4306/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.