Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PPP1R15A | O75807 | 1/20 | 0.40 |
| ▸ | MELK | Q14680 | 1/20 | 0.40 |
| ▸ | PPP1R15B | Q5SWA1 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5803252 | 1.00 | HPGD (0.45) | HPGDALDH1A1L3MBTL1LMNAHTT | |
| SCHEMBL2443441 | 1.00 | HPGD (0.45) | HPGDALDH1A1L3MBTL1LMNAHTT | |
| SCHEMBL18508494 | 0.82 | L3MBTL1 (0.37) | HPGDALDH1A1L3MBTL1LMNAHTT | |
| SCHEMBL18502957 | 0.82 | L3MBTL1 (0.37) | HPGDALDH1A1L3MBTL1LMNAHTT | |
| SCHEMBL1614520 | 0.80 | PPP1R15A (0.36) | HPGDALDH1A1L3MBTL1LMNAHTT | |
| SCHEMBL2161103 | 0.79 | L3MBTL1 (0.59) | HPGDALDH1A1L3MBTL1LMNAHTT | |
| SCHEMBL2161977 | 0.79 | ALDH1A1 (0.47) | HPGDALDH1A1L3MBTL1LMNAHTT | |
| SCHEMBL534016 | 0.79 | L3MBTL1 (0.59) | HPGDALDH1A1L3MBTL1LMNAHTT | |
| SCHEMBL32680261 | 0.79 | L3MBTL1 (0.59) | HPGDALDH1A1L3MBTL1LMNAHTT | |
| SCHEMBL534017 | 0.79 | L3MBTL1 (0.59) | HPGDALDH1A1L3MBTL1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2366704-B1 | Inhibitors of serine proteases | VERTEX PHARMA (US) | 2013-10-23 | — | — | EP | disclosed |
| EP-2631238-A1 | Spirocyclic inhibitors of serine proteases for the treatment of hcv infections | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-08-28 | — | — | EP | disclosed |
| EP-1917269-B1 | INHIBITORS OF SERINE PROTEASES | VERTEX PHARMA (US) | 2011-10-26 | — | — | EP | disclosed |
| EP-2366704-A1 | Inhibitors of serine proteases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-09-21 | — | — | EP | disclosed |
| EP-2364984-A1 | Inhibitors of serine proteases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-09-14 | — | — | EP | disclosed |