Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 5/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | WNT1 | P04628 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29601370 | 1.00 | ROCK2 (0.41) | ROCK2KDM4COPRM1OPRL1PIM1 | |
| SCHEMBL24437151 | 0.87 | CNR1 (0.48) | ROCK2KDM4CCNR1 | |
| SCHEMBL24437158 | 0.85 | HTR3A (0.44) | ROCK2KDM4COPRM1OPRL1PIM1 | |
| SCHEMBL24437200 | 0.83 | CNR1 (0.51) | ROCK2KDM4COPRM1OPRL1CNR1 | |
| SCHEMBL29601435 | 0.81 | KDM4C (0.52) | ROCK2KDM4CCNR1WNT1MAPK14 | |
| SCHEMBL29600940 | 0.81 | KDM4C (0.58) | KDM4CMAPK14HDAC1HDAC2 | |
| SCHEMBL24437135 | 0.81 | KDM4C (0.52) | ROCK2KDM4CCNR1WNT1MAPK14 | |
| SCHEMBL24437301 | 0.81 | KDM4C (0.58) | KDM4CMAPK14HDAC1HDAC2 | |
| SCHEMBL24437270 | 0.80 | KDM4C (0.51) | ROCK2KDM4CWNT1MAPK14HDAC1 | |
| SCHEMBL24437216 | 0.80 | KDM4C (0.48) | ROCK2KDM4CCNR1WNT1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220153735-A1 | Orai Channel Inhibitors | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. | 2022-05-19 | — | — | US | disclosed |
| US-20220153735-A1 | Orai Channel Inhibitors | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. | 2022-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220153735-A1 | Orai Channel Inhibitors | ORAI2, ORAI1, ORAI3 | ROCK2 1486/4885KDM4C 3959/4885OPRM1 1031/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.