Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.38 |
| ▸ | SELE | P16581 | 1/20 | 0.38 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14622099 | 0.86 | KDM4E (0.44) | KDM4ESMN1; SMN2MEN1HTTKMT2A | |
| SCHEMBL5461755 | 0.86 | MRGPRX4 (0.49) | KDM4ESMN1; SMN2MEN1HTTKMT2A | |
| SCHEMBL24440339 | 0.85 | KDM4E (0.48) | KDM4ESMN1; SMN2MEN1HTTKMT2A | |
| SCHEMBL486062 | 0.84 | KDM4E (0.44) | KDM4ESMN1; SMN2MEN1HTTKMT2A | |
| SCHEMBL17075501 | 0.82 | PARP1 (0.44) | KDM4ESMN1; SMN2MEN1KMT2AGABRA1 | |
| SCHEMBL26435287 | 0.81 | MRGPRX4 (0.40) | KDM4ESMN1; SMN2MEN1KMT2APARP1 | |
| SCHEMBL31410740 | 0.80 | KDM4E (0.40) | KDM4ESMN1; SMN2MEN1HTTKMT2A | |
| SCHEMBL44672 | 0.80 | GABRA1 (0.48) | KDM4ESMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL83923 | 0.79 | KDM4E (0.50) | KDM4EMEN1HTTKMT2AALDH1A1 | |
| SCHEMBL8089369 | 0.78 | GABRA1 (0.42) | KDM4ESMN1; SMN2MEN1HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022100710-A1 | TYROSINE KINASE 2 (TYK2) DEGRADATION COMPOUNDS AND METHODS OF USE | CULLGEN (SHANGHAI) , INC. (CN) | 2022-05-19 | — | — | WO | disclosed |