Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | LIG1 | P18858 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CXCR5 | P32302 | 2/20 | 0.38 |
| ▸ | TLR4 | O00206 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL299375 | 0.87 | SMN1; SMN2 (0.46) | KDM4ECYP3A4LIG1ALDH1A1TSHR | |
| SCHEMBL24440337 | 0.84 | KDM4E (0.43) | KDM4EALDH1A1HSD17B10SMN1; SMN2HTT | |
| SCHEMBL1520942 | 0.81 | CXCR5 (0.55) | KDM4ECYP3A4LIG1ALDH1A1TSHR | |
| SCHEMBL11602955 | 0.81 | GABRA1 (0.47) | KDM4EALDH1A1TSHRSMN1; SMN2HPGD | |
| SCHEMBL6365179 | 0.79 | SCN1A (0.38) | KDM4ELIG1ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL83923 | 0.77 | KDM4E (0.50) | KDM4ECYP3A4ALDH1A1TSHRHSD17B10 | |
| SCHEMBL7870129 | 0.76 | GABRA1 (0.44) | KDM4ECYP3A4ALDH1A1TSHRHSD17B10 | |
| SCHEMBL8824319 | 0.76 | GABRA1 (0.44) | KDM4ECYP3A4ALDH1A1TSHRHSD17B10 | |
| SCHEMBL12611132 | 0.76 | GABRA1 (0.58) | KDM4EALDH1A1TSHRHSD17B10SMN1; SMN2 | |
| SCHEMBL27420156 | 0.76 | GABRA1 (0.44) | KDM4EALDH1A1TSHRHSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411388-A2 | PROCESS FOR THE PRODUCTION OF FUSED, TRICYCLIC SULFONAMIDES | Elan Pharmaceuticals Inc. (US) | 2012-02-01 | — | — | EP | disclosed |
| WO-2010111418-A2 | PROCESS FOR THE PRODUCTION OF FUSED, TRICYCLIC SULFONAMIDES | ELAN PHARMACEUTICALS, INC. (US) | 2010-09-30 | — | — | WO | disclosed |