Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.50 |
| ▸ | AR | P10275 | 2/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24440457 | 0.90 | RAB9A (0.51) | RAB9ASMN1; SMN2KMT2AMAPTMEN1 | |
| SCHEMBL17243071 | 0.83 | RAB9A (0.61) | RAB9ASMN1; SMN2KMT2AMAPTMEN1 | |
| SCHEMBL24440624 | 0.80 | C1S (0.45) | RAB9ASMN1; SMN2KMT2AMAPTMEN1 | |
| SCHEMBL30208793 | 0.77 | MAPK1 (0.51) | CDK5CDK5R1MAPK1AXLMKNK2 | |
| SCHEMBL24440736 | 0.77 | NPC1 (0.56) | RAB9ASMN1; SMN2KMT2AMAPTMEN1 | |
| SCHEMBL24440732 | 0.76 | KMT2A (0.54) | RAB9ASMN1; SMN2KMT2AMAPTMEN1 | |
| SCHEMBL98272 | 0.75 | ROCK1 (0.62) | RAB9ASMN1; SMN2KMT2AMAPTMEN1 | |
| SCHEMBL11213832 | 0.74 | RAB9A (0.77) | RAB9ASMN1; SMN2KMT2AMAPTMEN1 | |
| SCHEMBL17243087 | 0.73 | MEN1 (0.84) | RAB9ASMN1; SMN2KMT2AMAPTMEN1 | |
| SCHEMBL24440465 | 0.73 | KMT2A (0.48) | RAB9ASMN1; SMN2KMT2AMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022104348-A1 | SMALL MOLECULE INHIBITORS OF NF-KB INDUCING KINASE | JANSSEN PHARMACEUTICA NV (BE) | 2022-05-19 | — | — | WO | disclosed |