Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | GLB1 | P16278 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | QARS1 | P47897 | 1/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.33 |
| ▸ | PTGFR | P43088 | 1/20 | 0.33 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.33 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 2/20 | 0.32 |
| ▸ | BLM | P54132 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10369813 | 1.00 | ALOX5 (0.40) | ALOX5GLB1LMNASLC22A6TSHR | |
| SCHEMBL13789828 | 0.89 | QARS1 (0.34) | ALOX5GLB1LMNAQARS1 | |
| SCHEMBL13789766 | 0.89 | QARS1 (0.34) | ALOX5GLB1LMNAQARS1 | |
| SCHEMBL4416941 | 0.89 | QARS1 (0.34) | ALOX5GLB1LMNAQARS1 | |
| SCHEMBL4420955 | 0.89 | QARS1 (0.34) | ALOX5GLB1LMNAQARS1 | |
| SCHEMBL3102769 | 0.80 | — | — | |
| SCHEMBL23802775 | 0.79 | LMNA (0.40) | ALOX5LMNASLC22A6TSHRPMP22 | |
| SCHEMBL23802831 | 0.79 | LMNA (0.40) | ALOX5LMNASLC22A6TSHRPMP22 | |
| SCHEMBL8512062 | 0.76 | ITGB3 (0.42) | LMNATSHRBLMKMT2AMEN1 | |
| SCHEMBL31202 | 0.76 | ITGB3 (0.42) | LMNATSHRBLMKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022104345-A1 | 1-(2-(4-CYCLOPROPYL-1H-1,2,3-TRIAZOL-1-YL)ACETYL)-4-HYDROXYPYRROLIDINE-2-CARBOXA|MIDE DERIVATIVES AS VHL INHIBITORS FOR THE TREATMENT OF ANEMIA | GENENTECH, INC. (US) | 2022-05-19 | — | — | WO | disclosed |